| A randomized comparison of 4 doses of intracoronary adenosine in the assessment of fractional flow reserve. | |
| | |
MedLine Citation:
|
PMID: 12955409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Fractional flow reserve (FFR) is a measure of coronary stenosis severity that is based on pressure measurements obtained at maximal hyperemia. Therefore, achievement of maximal vasodilatation of the coronary microcirculation is a prerequisite for the measurement of FFR. The study was designed to address the hypothesis that intracoronary adenosine yields more complete vasodilatation of the coronary microcirculation when high doses are used, resulting in a more accurate FFR measurement. METHODS: Thirty-six patients with 43 moderate lesions underwent determination of FFR during cardiac catheterization. FFR was calculated in all lesions as the ratio of the distal coronary pressure to the aortic pressure at hyperemia. Different incremental doses of intracoronary adenosine (16, 24, 32 and 40 microg for both coronary arteries) were administered in a randomized fashion. RESULTS: No adverse events occurred with any intracoronary adenosine bolus. At baseline there were no significant differences for mean aortic and distal coronary pressure, heart rate as well as FFR values between the different doses. FFR was not significantly altered from the different incremental adenosine doses. However, in 27 (63%) out of 43 lesions there was a further reduction of FFR up to 0.23 when a dose >16 microg was injected. CONCLUSIONS: This study suggests that doses of adenosine up to 40 microg are safe and can be used to achieve a more pronounced vasodilatation in individual patients compared to the standard doses. This may have therapeutic impact with FFR values near cut-off points in patients undergoing diagnostic coronary angiography as well as in patients in whom FFR is used to assess the outcome of interventions. |
| | |
Authors:
|
G Casella; J Rieber; T M Schiele; H-U Stempfle; U Siebert; M Leibig; K Theisen; U Buchmeier; V Klauss |
Related Documents
:
|
3882619 - Comparison of an ionic with a nonionic contrast agent for cardiac angiography. results ... 9085349 - Role of nitric oxide (no) in the regulation of coronary circulation. 7047179 - Effects of prostacyclin (pgi2) on vulnerability to ventricular fibrillation in the norm... 21300709 - Conventional versus automated measurement of blood pressure in primary care patients wi... 7425139 - Progressive myocardial dysfunction associated with increased vascular resistance. 1903819 - The interaction of vasodilating drugs and sympathetic blockade in normal and ischemic c... 17584099 - C-reactive protein and hypertension: is there a causal relationship? 10392679 - Influence of combined zero-balanced and modified ultrafiltration on the systemic inflam... 20330979 - Characterization of a high-frequency pressure-field calibration method. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Zeitschrift für Kardiologie Volume: 92 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-09-04 Completed Date: 2004-01-16 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 627-32 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Ospedale Maggiore, Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
administration & dosage*,
pharmacology Adult Aged Aged, 80 and over Coronary Angiography Coronary Circulation* / drug effects, physiology Coronary Stenosis / diagnosis*, physiopathology, radiography Coronary Vessels Data Interpretation, Statistical Female Heart Catheterization Heart Rate Hemodynamics Humans Hyperemia / physiopathology Injections, Intra-Arterial Male Microcirculation / physiology Middle Aged Vasodilation / physiology Vasodilator Agents / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure of the Australian system of 'Diagnosis Related Groups' regarding cardiovascular diseases a...
Next Document: Coronary stent implantation in elderly patients: acute and long-term results