Document Detail

A randomized comparative trial of the efficacy and safety of exercise during pregnancy: design and methods.
MedLine Citation:
PMID:  16861054     Owner:  NLM     Status:  MEDLINE    
Use of an exercise intervention for high-risk and vulnerable populations, such as pregnant women at risk for gestational hypertension or preeclampsia, requires special consideration. A comparative trial testing the effects of two types of physical exercises - stretching (a comparator) and walking (a testing intervention) - for sedentary pregnant women at risk for preeclampsia - is presented in this paper. The study was designed to reduce post-randomization bias and dropout rates from both groups, and closely to monitor safety of subjects. The strengths of the study design and methods include use of a run-in phase; use of a stretching exercise as a comparator; multiple ways to measure daily physical activities and the exercise intervention; and tailored support to remove barriers to exercise for subjects. The intervention consists of 40 min of walking at moderate intensity (i.e., 55-69% of maximum heart rate and rating of perceived exhaustion 12-13) five times a week from 18 weeks gestation until birth. The comparator exercise consists of 40 min of stretching exercise without increasing heart rate to more than 10% of resting heart rate, five times a week from 18 weeks gestation until birth. The primary outcome is the incidence of preeclampsia. Secondary outcomes include the physiologic effects of the intervention and birth outcomes.
SeonAe Yeo
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2006-07-24
Journal Detail:
Title:  Contemporary clinical trials     Volume:  27     ISSN:  1551-7144     ISO Abbreviation:  -     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-40     Citation Subset:  IM    
University of Michigan School of Nursing, Division of Health Promotion and Risk Reduction, 400 North Ingalls, Ann Arbor, Michigan 48109, United States.
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MeSH Terms
Diabetes, Gestational / therapy*
Hypertension, Pregnancy-Induced / therapy*
Muscle Stretching Exercises
Pre-Eclampsia / therapy*
Research Design
Treatment Outcome

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