Document Detail

A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy.
MedLine Citation:
PMID:  18759524     Owner:  NLM     Status:  MEDLINE    
Chronic anal fissure is one of the most common causes of anal pain and surgical therapy is the treatment of choice. There is scarce information regarding the prophylactic effects of oral metronidazole on postoperative complications of anal fissure. The objective of this study was to determine the effects of metronidazole as a prophylactic measure for postoperative anal fissure complications. In a numerical randomized clinical trial, 311 patients with anal fissure were randomized into two groups. The group which received prophylactic oral metronidazole was compared to the control group regarding wound dehiscence, bleeding, discharge, and pain after one and two weeks of operation. One hundred fifty-six patients with mean+/-SD age of 36+/-7.3 years were in metronidazole group and 155 patients with mean+/-SD age of 38+/-7.1 years were in the control group. Regarding the studied outcome variables, the patients in both groups did not have any significant differences after one and two weeks. Our results did not support the prophylactic use of metronidazole in reducing postsurgical complications after internal sphincterotomy of anal fissure.
Seyed Vahid Hosseini; Babak Sabet; Mohamoud Nouri Amirkolaee; Shahram Bolandparvaz
Related Documents :
12617884 - Diagnosis and treatment of pouchitis.
20645104 - Seton drainage prior to transanal advancement flap repair: useful or not?
10696894 - Preliminary experience in management of fecal incontinence caused by internal anal sphi...
8607574 - Functional outcome of the double stapled ileoanal reservoir in patients more than 60 ye...
20718184 - Home mechanical ventilation: outcomes according to remoteness from health center and di...
22333864 - Patient perspective survey of total hip vs total knee arthroplasty surgery.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  11     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2009-08-25     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  550-2     Citation Subset:  IM    
Gastroenterohepatology Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Anal Canal / surgery*
Anti-Infective Agents / administration & dosage*
Fissure in Ano / surgery*
Metronidazole / administration & dosage*
Pain, Postoperative / prevention & control*
Postoperative Complications
Wound Healing / drug effects*
Reg. No./Substance:
0/Anti-Infective Agents; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association of cys 311 ser polymorphism of paraoxonase-2 gene with the risk of coronary artery disea...
Next Document:  Presence of lead in opium.