Document Detail


A randomized clinical study comparing reduced-volume oral sulfate solution with standard 4-liter sulfate-free electrolyte lavage solution as preparation for colonoscopy.
MedLine Citation:
PMID:  20646695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Low-volume bowel preparations for colonoscopy improve tolerability.
OBJECTIVE: We compared the efficacy, tolerability, and safety of a new low-volume sulfate solution with a standard 4-L polyethylene glycol electrolyte lavage solution as bowel preparation for colonoscopy.
DESIGN: Multicenter, single-blind, randomized, noninferiority study.
SETTING: Five academic and community endoscopy centers in the United States.
PATIENTS: One hundred thirty-six outpatients undergoing colonoscopy.
INTERVENTIONS: Patients were randomized to receive 4 L sulfate-free electrolyte lavage solution (SF-ELS) given the night before colonoscopy versus 12 oz oral sulfate solution (OSS) given in equally divided doses the evening before and the morning of colonoscopy.
MAIN OUTCOME MEASUREMENTS: Successful (ie, good or excellent) bowel preparation.
RESULTS: Successful bowel preparation was more frequent with OSS than with SF-ELS (98.4% vs 89.6%; P = .04). Excellent preparation also was achieved more frequently with OSS (71.4% vs 34.3%; P < .001). Patients receiving OSS had less residual stool in the cecum and ascending colon and less residual fluid in the cecum and ascending, transverse, and descending colon compared with SF-ELS. The percentage of patients with GI side effects and adverse events was not significantly different between the 2 groups.
LIMITATIONS: The OSS was administered in split doses, whereas the SF-ELS was administered the evening before (which is its FDA-approved regimen).
CONCLUSIONS: Oral sulfate solution is promising as a safe low-volume preparation for colonoscopy. (
CLINICAL TRIAL REGISTRATION NUMBER: NCT00856843.).
Authors:
Douglas K Rex; Jack A Di Palma; Reynaldo Rodriguez; John McGowan; Mark Cleveland
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2010-06-19
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  72     ISSN:  1097-6779     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-36     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00856843
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Analgesics / administration & dosage
Cathartics / administration & dosage
Colonoscopy / methods*
Defecation / drug effects
Drug Combinations
Female
Follow-Up Studies
Humans
Magnesium Sulfate / administration & dosage*
Male
Middle Aged
Reproducibility of Results
Single-Blind Method
Sulfates / administration & dosage*
Therapeutic Irrigation / methods
Chemical
Reg. No./Substance:
0/Analgesics; 0/Cathartics; 0/Drug Combinations; 0/Sulfates; 0YPR65R21J/sodium sulfate; 1K573LC5TV/potassium sulfate; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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