| A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure. | |
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MedLine Citation:
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PMID: 15200038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare a systemic transdermal therapeutic system with local application of glyceryl trinitrate ointment in the treatment of anal fissure. DESIGN: Prospective, multicentre, randomised trial. SETTING: Three teaching hospitals, Turkey. SUBJECTS: 89 outpatients with chronic anal fissure were randomly assigned to be treated with either transdermal (n = 52) or 0.2% glyceryl trinitrate ointment (n = 37). INTERVENTIONS: The patients were assessed at the sixth and the twelfth week after initial evaluation by physical examination, anoscopy, and anal manometry. MAIN OUTCOME MEASURES: Changes in the maximal anal resting pressure, healing rate. RESULTS: Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively. Maximal anal resting pressure was reduced by 24% and 21% in transdermal and ointment groups, respectively. CONCLUSION: Systemic transdermal application of glyceryl trinitrate gave a satisfactory healing rate, which was comparable to that of local application of ointment. |
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Authors:
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Tahsin Colak; Turgut Ipek; Namik Urkaya; Arzu Kanik; Musa Dirlik |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: The European journal of surgery. Supplement. : = Acta chirurgica. Supplement Volume: - ISSN: 1102-416X ISO Abbreviation: Eur J Surg Suppl Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2004-06-17 Completed Date: 2004-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9114489 Medline TA: Eur J Surg Suppl Country: Norway |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: IM |
Affiliation:
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Mersin University Medical Faculty, Department of General Surgery, Mersin, Turkey. tcolak@mersin.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Topical Adult Chronic Disease Female Fissure in Ano / drug therapy* Humans Male Middle Aged Nitroglycerin / administration & dosage* Ointments |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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