Document Detail


A randomised study of GnRH antagonist (cetrorelix) versus agonist (busereline) for controlled ovarian stimulation: effect on safety and efficacy.
MedLine Citation:
PMID:  15925049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess safety and efficacy of cetrorelix utilisation in controlled ovarian stimulation (COS).
STUDY DESIGN: Phase III, randomized, single center study of 131 patients undergoing COS and IVF with or without ICSI, in a University affiliated Hospital. Sixty-six patients were allocated to the protocol with antagonist and 65 to the agonist protocol arm. The Student's t-test, the Mann-Whitney test and the chi-square test were applied as required, using SPSS for Windows with a two-sided 5% significance level.
RESULTS: The mean (+/-S.D.) duration of stimulation was 9.5+/-1.7 days in the antagonist group and 10.6+/-2.1 days in the agonist group (P=0.02). The mean (+/-S.D.) duration of suppression was 4.6+/-1.3 days in the antagonist group and 27.3+/-5.2 days in the agonist group (P<0.0001). No significant differences were noted in other outcome measures: amount of rFSH required, estradiol level on hCG day, number of follicles>or=15 mm and endometrial thickness on oocyte retrieval day, number of oocytes retrieved, fertilization rate and number of OHS cases. Clinical pregnancy rates per-attempt and per-transfer were 15.1% and 17.0% in the antagonist group and 16.9% and 20.0% in the agonist group (P=0.79 and 0.71, respectively).
CONCLUSIONS: GnRH antagonists are an effective, safe and well tolerated alternative to agonists for COS.
Authors:
Pedro Xavier; Cristina Gamboa; Lucinda Calejo; Joaquina Silva; David Stevenson; Adelina Nunes; José Martinez-de-Oliveira
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  120     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-31     Completed Date:  2005-12-07     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Affiliation:
Unidade de Reprodução Medicamente Assistida, Departamento de Ginecologia e Obstetrícia, Hospital de São João, Faculdade de Medicina do Porto, Portugal. cpxavier@mail.telepac.pt
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MeSH Terms
Descriptor/Qualifier:
Adult
Buserelin / administration & dosage*,  adverse effects
Chorionic Gonadotropin / administration & dosage
Estradiol / blood
Female
Fertilization in Vitro
Follicle Stimulating Hormone / administration & dosage
Gonadotropin-Releasing Hormone / administration & dosage,  adverse effects,  agonists*,  analogs & derivatives*,  antagonists & inhibitors*
Humans
Ovarian Hyperstimulation Syndrome / epidemiology
Ovulation Induction / methods*
Pregnancy
Sperm Injections, Intracytoplasmic
Treatment Outcome
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57982-77-1/Buserelin; 9002-68-0/Follicle Stimulating Hormone; OON1HFZ4BA/cetrorelix

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