| A randomised prospective study comparing the effectiveness of esomeprazole treatment strategies in clinical practice for 6 months in the management of patients with symptoms of gastroesophageal reflux disease. | |
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MedLine Citation:
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PMID: 15924594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One option for patients with symptoms of gastroesophageal reflux disease (GERD) is treatment with proton pump inhibitors without prior endoscopy. Continuous or on-demand maintenance therapy are options for symptom-free patients. This study assessed the efficacy of three different treatment options in GERD patients in Norway. About 395 General Practitioners enrolled 2156 patients with symptoms of GERD in an open, randomised, parallel group trial. Following a 4-week symptom control phase [esomeprazole 40 mg once daily (od)], patients received either esomeprazole 20 mg od continuously or on-demand or ranitidine 150 mg twice-daily continuously for 6 months. The percentage of patients with no heartburn at the end of the study was maintained most effectively in the esomeprazole 20 mg continuous group (72.2%) and least effectively in the ranitidine group (32.5%). Significantly, more patients were completely/very satisfied with esomeprazole continuous (82.2%) and esomeprazole on-demand (75.4%) than with ranitidine continuous (33.5%) treatment (p < 0.0001). More patients were kept in remission, symptom free and were overall more satisfied with esomeprazole treatment than ranitidine. |
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Authors:
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A Norman Hansen; R Bergheim; H Fagertun; H Lund; B Moum |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of clinical practice Volume: 59 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-31 Completed Date: 2005-08-18 Revised Date: 2013-01-07 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 665-71 Citation Subset: IM |
Affiliation:
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Harbitzallèen Legesenter, Oslo, Norway. age.normanhansen@harbitzalleen.onh.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Ulcer Agents / administration & dosage* Drug Administration Schedule Esomeprazole Sodium / administration & dosage* Female Gastroesophageal Reflux / drug therapy* Humans Long-Term Care Male Middle Aged Norway Patient Satisfaction Prospective Studies Proton Pumps / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Proton Pumps; L2C9GWQ43H/Esomeprazole Sodium |
| Comments/Corrections | |
Erratum In:
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Int J Clin Pract. 2005 Nov;59(11):1371 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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