Document Detail

A randomised prospective comparison of oral ofloxacin and intraperitoneal vancomycin plus aztreonam in the treatment of bacterial peritonitis complicating continuous ambulatory peritoneal dialysis (CAPD).
MedLine Citation:
PMID:  2049419     Owner:  NLM     Status:  MEDLINE    
Forty six patients who developed 48 episodes of peritonitis while on CAPD were randomised to receive either oral ofloxacin or intraperitoneal (i.p.) vancomycin/aztreonam. Three patients were excluded from analysis: 2 were transferred to other hospitals and 1 was later found to have candida peritonitis. Of the remainder, 22 episodes were treated with oral ofloxacin and 23 with i.p. vancomycin/aztreonam. The primary cure rate in the oral ofloxacin and i.p. vancomycin/aztreonam group was 77.3% and 87.5% respectively. There were 3 primary failures and 2 relapses in the former and 1 failure and 2 relapses in the latter group. Two of the 4 primary failures were peritonitis episodes secondary to infection with pseudomonas species. The total number of days of hospital stay was 48 and 58 respectively in the two groups. Analysis of the cost of treatment revealed that i.p. vancomycin/aztreonam was 30 times more expensive than oral ofloxacin. Despite a slightly higher cure rate with i.p. vancomycin/aztreonam, oral ofloxacin is a more cost-effective primary treatment of bacterial peritonitis in patients on CAPD especially in countries with a limited health budget.
I K Cheng; C Y Chan; W T Wong
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  11     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-22     Completed Date:  1991-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  27-30     Citation Subset:  IM    
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
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MeSH Terms
Administration, Oral
Aztreonam / administration & dosage
Bacterial Infections / drug therapy*
Drug Therapy, Combination / therapeutic use*
Ofloxacin / administration & dosage,  therapeutic use*
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
Peritonitis / drug therapy*,  microbiology
Vancomycin / administration & dosage
Reg. No./Substance:
1404-90-6/Vancomycin; 78110-38-0/Aztreonam; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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