Document Detail

A randomised placebo controlled trial of preoperative carbohydrate drinks and early postoperative nutritional supplement drinks in colorectal surgery.
MedLine Citation:
PMID:  23406311     Owner:  NLM     Status:  Publisher    
AIM: There is evidence that preoperative carbohydrate drinks and postoperative nutritional supplements toghether improve the outcome of colorectal surgery. There is little information on their individual contribution. METHOD: A prospective four-arm double blind controled trial was varied out in which patients were randomised to carbohydrate or placebo drinks preoperatively or a polymeric supplement or placebo drink postoperatively. The primary outcome was insulin resistance (using the short insulin tolerance test and HOMA IR). Secondary outcomes included handgrip strength, pulmonary function, intestinal permeability and postoperative complications. RESULTS: 120 patients were randomised to four demographically well matched groups. Patients who received pre and postoperative supplements had better glucose homeostasis (p=0.004), PEFR (p=0.035), handgrip strength (p=0.002) and less insulin resistance (p=0.001) compared with those who only received placebo drinks. CONCLUSION: Oral nutritional supplements given pre and postoperation improve post-operative handgrip strength, pulmonary function and insulin resistance. A weaker effect was seen in patients who received supplements either pre or postoperatively. Oral nutritional supplements should be given both pre and postoperatively. © 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Paul Lidder; Steve Thomas; Simon Fleming; Kenneth Hosie; Stephen Shaw; Stephen Lewis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-13
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  -     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Department of Surgery, Derriford Hospital, Plymouth, UK.
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