Document Detail

A randomised controlled trial of the effect of high concentration oxygen on myocardial ischaemia during exercise.
MedLine Citation:
PMID:  21570139     Owner:  NLM     Status:  Publisher    
BACKGROUND: International guidelines recommend the use of oxygen for angina, based on Level C evidence. We aimed to determine whether high concentration oxygen influences the time to exercise-induced ischaemia or angina in patients with stable ischaemic heart disease (IHD). METHODS: 22 subjects with IHD and a positive exercise treadmill test (ETT) awaiting coronary angiography were randomised to two further ETTs according to a double-blind, crossover study design, during which they breathed oxygen or air at 15L/min via a non-rebreather mask. Subjects in whom significant coronary artery disease was not subsequently confirmed by coronary angiography were excluded from analysis. The primary outcome was time to exercise-induced myocardial ischaemia, defined as ≥1mm ST depression on contiguous electrocardiographic (ECG) leads. The secondary outcome was time to onset of angina. RESULTS: Exercise-induced myocardial ischaemia occurred in 17 of the 19 subjects with coronary artery disease, with the remaining two stopping due to shortness of breath. The mean (SD) time to inducible ischaemia was 35 (47) s longer (95% CI 11 to 59, P=0.007) with oxygen compared to air. Exercise-induced angina occurred in 9 subjects and started a mean 19 (32) s later (95% CI -6 to 43, P=0.12) with oxygen compared to air. All subjects who developed myocardial ischaemia or angina did so during both of the study ETTs. CONCLUSION: High concentration oxygen increases the time to onset of exercise-induced myocardial ischaemia in patients with stable IHD.
Anil M Ranchord; Kyle Perrin; Mark Weatherall; Richard Beasley; Mark Simmonds
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-11
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Department of Cardiology, Capital & Coast District Health Board, Wellington, New Zealand.
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