Document Detail

A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source.
MedLine Citation:
PMID:  19201180     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In humans, n-3 long-chain polyunsaturated fatty acids play a well-documented role in brain development and function. Docosahexaenoic acid and arachidonic acid are major structural components of the brain and a deficiency thereof may bring about changes in the behaviour domains of the brain. OBJECTIVE: This trial investigated the effect of an experimental fish-flour bread spread rich in n-3 long-chain polyunsaturated fatty acids, on cognition of children (7-9yr). DESIGN: Subjects (n=183) were randomly assigned to an experimental (n=91) and control group (n=92), receiving either the fish-flour spread or a placebo spread for 6 months in a single-blind study. Plasma and red blood cell phospholipid fatty acid composition and cognition were measured at baseline and post-intervention. RESULTS: After the intervention, eicosapentaenoic and docosahexaenoic acid levels were significantly higher in the experimental group compared to the control group (p< 0.0001). Significant intervention effects were also observed for the Hopkins Verbal Learning Test Recognition (estimated effect size: 0.80; 95% confidence interval (CI): 0.15; 1.45) and Discrimination Index (estimated effect size: 1.10; 95% CI: 0.30; 1.91), as well as the Spelling test (estimated effect size: 2.81; 95% CI: 0.59; 5.02) by both per protocol and intention to treat analyses. A marginally significant (p=0.0646) effect was observed for the Reading test (estimated effect size: 2.21; 95% CI: -0.14; 4.56) only in the per protocol analysis. CONCLUSION: This study suggests improvement of verbal learning ability and memory of children when supplemented with a fish-flour spread rich in n-3 long-chain polyunsaturated fatty acids.
Annalien Dalton; Petronella Wolmarans; Regina C Witthuhn; Martha E van Stuijvenberg; Sonja A Swanevelder; Cornelius M Smuts
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-02-06
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  80     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2009 Feb-Mar
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Nutritional Intervention Research Unit, Medical Research Council, P.O. Box 19070, Tygerberg 7505, South Africa.
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MeSH Terms
Arachidonic Acid / analysis
Cognition / drug effects*,  physiology*
Dietary Supplements*
Docosahexaenoic Acids / analysis
Eicosapentaenoic Acid / analysis
Erythrocyte Membrane / chemistry
Fish Flour* / analysis
Learning / drug effects
Phospholipids / blood,  chemistry
Plant Oils / pharmacology
Reg. No./Substance:
0/Phospholipids; 0/Plant Oils; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 8002-75-3/palm oil

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