| A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. | |
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MedLine Citation:
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PMID: 19201180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In humans, n-3 long-chain polyunsaturated fatty acids play a well-documented role in brain development and function. Docosahexaenoic acid and arachidonic acid are major structural components of the brain and a deficiency thereof may bring about changes in the behaviour domains of the brain. OBJECTIVE: This trial investigated the effect of an experimental fish-flour bread spread rich in n-3 long-chain polyunsaturated fatty acids, on cognition of children (7-9yr). DESIGN: Subjects (n=183) were randomly assigned to an experimental (n=91) and control group (n=92), receiving either the fish-flour spread or a placebo spread for 6 months in a single-blind study. Plasma and red blood cell phospholipid fatty acid composition and cognition were measured at baseline and post-intervention. RESULTS: After the intervention, eicosapentaenoic and docosahexaenoic acid levels were significantly higher in the experimental group compared to the control group (p< 0.0001). Significant intervention effects were also observed for the Hopkins Verbal Learning Test Recognition (estimated effect size: 0.80; 95% confidence interval (CI): 0.15; 1.45) and Discrimination Index (estimated effect size: 1.10; 95% CI: 0.30; 1.91), as well as the Spelling test (estimated effect size: 2.81; 95% CI: 0.59; 5.02) by both per protocol and intention to treat analyses. A marginally significant (p=0.0646) effect was observed for the Reading test (estimated effect size: 2.21; 95% CI: -0.14; 4.56) only in the per protocol analysis. CONCLUSION: This study suggests improvement of verbal learning ability and memory of children when supplemented with a fish-flour spread rich in n-3 long-chain polyunsaturated fatty acids. |
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Authors:
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Annalien Dalton; Petronella Wolmarans; Regina C Witthuhn; Martha E van Stuijvenberg; Sonja A Swanevelder; Cornelius M Smuts |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-02-06 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 80 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2009 Feb-Mar |
Date Detail:
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Created Date: 2009-03-16 Completed Date: 2009-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 143-9 Citation Subset: IM |
Affiliation:
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Nutritional Intervention Research Unit, Medical Research Council, P.O. Box 19070, Tygerberg 7505, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid
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analysis Child Cognition / drug effects*, physiology* Dietary Supplements* Docosahexaenoic Acids / analysis Eicosapentaenoic Acid / analysis Erythrocyte Membrane / chemistry Female Fish Flour* / analysis Humans Learning / drug effects Male Phospholipids / blood, chemistry Plant Oils / pharmacology Reading |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 0/Plant Oils; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 8002-75-3/palm oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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