Document Detail

The radioprotective effects of bu-zhong-yi-qi-tang: a prescription of traditional Chinese medicine.
MedLine Citation:
PMID:  12067087     Owner:  NLM     Status:  MEDLINE    
We evaluated the effect of bu-zhong-yi-qi-tang, a prescription of traditional Oriental medicine, and its major ingredients on protection of the intestine and hematopoietic organs against radiation damage in this study. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low doses of gamma-rays. bu-zhong-yi-qi-tang administration before irradiation protected the jejunal crypts (p < 0.0001), increased the formation of the endogenous spleen colony (p < 0.05) and reduced the frequency of radiation-induced apoptosis (p < 0.05). In experiments on the effects of the individual ingredient of bu-zhong-yi-qi-tang, Rensan (Radix Ginseng), Danggui (Radix Angelicae gigantis), Shengma (Rhizoma Cimicifugae) and Chaihu (Radix Bupleuri) might have major radioprotective effects, and each might have different degrees of effect on these three endpoints. These results indicated that bu-zhong-yi-qi-tang might be a better agent than any one of its ingredients to satisfy all three endpoints. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that bu-zhong-yi-qi-tang might be a useful radioprotector, especially since it is a relatively non-toxic natural product. Further studies are needed to better characterize the protective nature of bu-zhong-yi-qi-tang extract and its ingredients.
Sung-Ho Kim; Song-Eun Lee; Heon Oh; Se-Ra Kim; Sung-Tae Yee; Young-Beob Yu; Myung-Woo Byun; Sung-Kee Jo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  30     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-17     Completed Date:  2002-12-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-37     Citation Subset:  IM    
Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Kwangju, South Korea.
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MeSH Terms
Apoptosis / drug effects,  radiation effects
Bone Marrow / drug effects,  radiation effects
Cell Survival / drug effects,  radiation effects
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drugs, Chinese Herbal / pharmacology*
Intestines / cytology,  drug effects,  radiation effects
Jejunum / cytology,  drug effects,  radiation effects
Mice, Inbred ICR
Radiation-Protective Agents / pharmacology*
Spleen / cytology,  drug effects,  radiation effects
Stem Cells
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Radiation-Protective Agents; 0/bu-zhong-yi-qi-tang

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