Document Detail


A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.
MedLine Citation:
PMID:  6310399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas. An assay has been developed to detect CA 125 in serum. By this assay, only 1 per cent of 888 apparently healthy persons and 6 per cent of 143 patients with nonmalignant disease had serum CA 125 levels above 35 U per milliliter. In contrast, 83 of 101 patients (82 per cent) with surgically demonstrated ovarian carcinoma had elevated levels of antigen. In 38 patients with epithelial ovarian carcinoma monitored on 2 to 18 occasions during 2 to 60 months, antigen levels ranged from less than 1 to more than 8000 U per milliliter. Rising or falling levels of CA 125 correlated with progression or regression of disease in 42 of 45 instances (93 per cent). Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer.
Authors:
R C Bast; T L Klug; E St John; E Jenison; J M Niloff; H Lazarus; R S Berkowitz; T Leavitt; C T Griffiths; L Parker; V R Zurawski; R C Knapp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  309     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  883-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / diagnosis,  immunology
Adenocarcinoma, Mucinous / diagnosis,  immunology
Adult
Antibodies, Monoclonal / immunology*
Antigens, Neoplasm / analysis*
Carcinoembryonic Antigen / analysis
Endometriosis / diagnosis,  immunology
Female
Humans
Male
Middle Aged
Monitoring, Physiologic
Ovarian Neoplasms / diagnosis*,  immunology,  therapy
Prognosis
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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