Document Detail

A radioimmunoassay for pregnancy associated protein, beta 1SP1: levels in pregnancy, trophoblastic and neoplastic disease.
MedLine Citation:
PMID:  6249709     Owner:  NLM     Status:  MEDLINE    
A radioimmunoassay system for the glycoprotein beta 1SP1, one of the pregnancy-associated proteins, has been set up. beta 1SP1 levels in normal pregnancy have been established transversally. Clearance (t1/2) from the circulation postpartum ranged from 1.4 to 1.8 days. Several patients with trophoblastic disease, e.g., mola hydatidosa, choriocarcinoma and embryonic cell carcinoma, were followed longitudinally. Human chorionic gonadotropin (hCG), a highly reliable tumor marker in trophoblastic disease, has been determined concomitantly by radioimmunoassay. In all instances, hCG proved to be a better indicator of the presence of a tumor, because by the time beta 1SP1 became undetectable, hCG could still be detected. Samples from a large multicenter study on trophoblastic disease were studied: out of 100 positive for hCG, beta 1SP1 could be detected in 86; however, out of 21 samples in which hCG was not detectable, 1 was found to be positive for beta 1SP1. In a number of samples from patients with bronchial carcinoma, no beta 1SP1 could be detected.
L H Elvers; G Hiemstra; R M Lequin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  12     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1980  
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  245-52     Citation Subset:  IM    
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MeSH Terms
Bronchial Neoplasms / metabolism
Choriocarcinoma / metabolism
Chorionic Gonadotropin / metabolism
Hydatidiform Mole / metabolism
Longitudinal Studies
Pregnancy Proteins / metabolism*
Pregnancy-Specific beta 1-Glycoproteins / metabolism*
Teratoma / metabolism
Trophoblastic Neoplasms / metabolism*
Uterine Neoplasms / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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