| A radioimmunoassay for pregnancy associated protein, beta 1SP1: levels in pregnancy, trophoblastic and neoplastic disease. | |
| | |
MedLine Citation:
|
PMID: 6249709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A radioimmunoassay system for the glycoprotein beta 1SP1, one of the pregnancy-associated proteins, has been set up. beta 1SP1 levels in normal pregnancy have been established transversally. Clearance (t1/2) from the circulation postpartum ranged from 1.4 to 1.8 days. Several patients with trophoblastic disease, e.g., mola hydatidosa, choriocarcinoma and embryonic cell carcinoma, were followed longitudinally. Human chorionic gonadotropin (hCG), a highly reliable tumor marker in trophoblastic disease, has been determined concomitantly by radioimmunoassay. In all instances, hCG proved to be a better indicator of the presence of a tumor, because by the time beta 1SP1 became undetectable, hCG could still be detected. Samples from a large multicenter study on trophoblastic disease were studied: out of 100 positive for hCG, beta 1SP1 could be detected in 86; however, out of 21 samples in which hCG was not detectable, 1 was found to be positive for beta 1SP1. In a number of samples from patients with bronchial carcinoma, no beta 1SP1 could be detected. |
| | |
Authors:
|
L H Elvers; G Hiemstra; R M Lequin |
Related Documents
:
|
3343339 - Serial evaluation of vasopressin release and thirst in human pregnancy. role of human c... 19573299 - Age and a single day-14 beta-hcg can predict ongoing pregnancy following ivf. 7698849 - Induction of spermatogenesis with gonadotrophins in chinese men with hypogonadotrophic ... 3690459 - Failure of daily measurements of hcg in urine to demonstrate a high rate of early embry... 10629019 - Detrimental effect of the combination of r164s with g238s in tem-1 beta-lactamase on th... 6763999 - Presence of immunoreactive luteinizing hormone-releasing factor in hydatidiform mole as... 8820009 - Intrafetal prostaglandin f2alpha administration for uterine evacuation in a case of int... 1377509 - Effects of prostanoids on the rat's myometrium in vitro during pregnancy. 2025819 - Cesarean sections in alberta from april 1979 to march 1988. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hormone research Volume: 12 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1980 |
Date Detail:
|
Created Date: 1980-10-27 Completed Date: 1980-10-27 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 245-52 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bronchial Neoplasms
/
metabolism Choriocarcinoma / metabolism Chorionic Gonadotropin / metabolism Female Humans Hydatidiform Mole / metabolism Longitudinal Studies Pregnancy* Pregnancy Proteins / metabolism* Pregnancy-Specific beta 1-Glycoproteins / metabolism* Radioimmunoassay Teratoma / metabolism Trophoblastic Neoplasms / metabolism* Uterine Neoplasms / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Chorionic Gonadotropin; 0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of carbohydrates in thyrotropin binding sites.
Next Document: Treatment in the seventies: a decade of refinement.