| A rabbit model for implanting continuous drug infusion pumps. | |
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MedLine Citation:
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PMID: 3828159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper describes a surgical technique for implanting a readily available, human-sized drug infusion pump in rabbits. We developed this technique in order to expand uses of implantable infusion pump technology in the laboratory. The dog, which has been the research animal of choice in previous studies using implantable pumps, can now be replaced by smaller, less expensive animals for similar or other laboratory purposes. This technique can be of particular importance in the study of atherosclerosis where the dog is a poor model and the rabbit an excellent one. In 18 rabbits with inferior vena cava cannulations, we were able to obtain 100% survival and constant solution delivery for up to and greater than 6 months. This technique is safe and reproducible. By employing a simple catheter modification and using special pump anchoring precautions, we found that we could successfully use a human-sized device in rabbit studies. Commentary is also made concerning the relative contributions to patency and vein sclerosis of catheter diameter and the infusate media. |
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Authors:
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E Esper; B D Wigness; S Dombrovskis; V Michalek; T D Rohde; H Buchwald |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: ASAIO transactions / American Society for Artificial Internal Organs Volume: 33 ISSN: 0889-7190 ISO Abbreviation: ASAIO Trans Publication Date: 1987 Jan-Mar |
Date Detail:
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Created Date: 1987-05-13 Completed Date: 1987-05-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8611947 Medline TA: ASAIO Trans Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 28-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Equipment Design Evaluation Studies as Topic Infusion Pumps* Methods Postoperative Care Postoperative Complications / epidemiology Preoperative Care Rabbits* |
| Grant Support | |
ID/Acronym/Agency:
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AM32736-02/AM/NIADDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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