Document Detail

A rabbit model of abdominal aortic aneurysm associated with intimal thickening.
MedLine Citation:
PMID:  10449989     Owner:  NLM     Status:  MEDLINE    
A model of abdominal aortic aneurysm with intimal thickening was developed in the rabbit. A segment of the abdominal aorta just proximal to the bifurcation (1 or 2 cm in length) was dissected and isolated with clamps. This segment was perfused by injecting physiologic saline or 100 U/ml of hog pancreatic elastase from the lumen. Perfusion was performed manually for 5 min and the peak pressure in the segment was between 300 and 400 mm Hg in order to cause aortic wall injury. After 4 weeks, animals that had received perfusion with elastase had aneurysms in the perfused segment on arteriography. None of the other animals developed aortic aneurysms. Histologically, the segments of aorta perfused with saline exhibited intimal hyperplasia. In addition to the intimal hyperplasia, the segments of aorta perfused with elastase solution showed lysis of the elastic lamellae in the media that resulted in aneurysm formation.
M Matsushita; H Kobayashi; K Oda; N Nishikimi; T Sakurai; Y Nimura
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  31     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1999  
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-13     Citation Subset:  IM    
First Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan.
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MeSH Terms
Aortic Aneurysm, Abdominal / etiology*,  pathology,  radiography
Arteriosclerosis / complications
Disease Models, Animal
Follow-Up Studies
Hyperplasia / chemically induced,  complications
Pancreatic Elastase / toxicity
Perfusion / adverse effects
Tunica Intima / pathology*
Reg. No./Substance:
EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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