| rRNA probes used to quantify the effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli. | |
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MedLine Citation:
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PMID: 12960649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Certain milk factors may help to promote the growth of a host-friendly colonic microflora (e.g. bifidobacteria, lactobacilli) and explain why breast-fed infants experience fewer and milder intestinal infections than those who are formula-fed. The effects of supplementation of formula with two such milk factors was investigated in this study. MATERIALS AND METHODS: Infant rhesus macaques were breast-fed, fed control formula, or formula supplemented with glycomacropeptide (GMP) or alpha-lactalbumin (alpha-LA) from birth to 5 months of age. Blood was drawn monthly and rectal swabs were collected weekly. At 4.5 months of age, 10(8) colony-forming units of enteropathogenic E.coli O127, strain 2349/68 (EPEC) was given orally and the response to infection assessed. The bacteriology of rectal swabs pre- and post-infection was determined by culture independent fluorescence in situ hybridization. RESULTS: Post-challenge, breast-fed infants and infants fed alpha-LA-supplemented formula had no diarrhea, whilst those infants fed GMP-supplemented formula had intermittent diarrhea. In infants fed control formula the diarrhea was acute. CONCLUSIONS: Supplementation of infant formula with appropriate milk proteins may be useful for improving the infant's ability to resist acute infection caused by E.coli. |
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Authors:
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Wolfram M Brück; Shannon L Kelleher; Glenn R Gibson; Karin E Nielsen; Dereck E W Chatterton; Bo Lönnerdal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 37 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-08 Completed Date: 2004-02-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 273-80 Citation Subset: IM |
Affiliation:
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Food Microbial Sciences Unit, School of Food Biosciences, The University of Reading, Reading, RG6 6AP, UK. w.m.bruck@reading.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bifidobacterium / growth & development Colony Count, Microbial Escherichia coli / drug effects, growth & development* Glycopeptides / administration & dosage* Humans In Situ Hybridization, Fluorescence Infant Infant Food Infant Formula* Infant Nutritional Physiological Phenomena* Infant, Newborn Lactalbumin / administration & dosage* Lactobacillus / growth & development Macaca mulatta Models, Animal RNA, Ribosomal / analysis Rectum / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Glycopeptides; 0/RNA, Ribosomal; 9013-90-5/Lactalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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