Document Detail


rCBF in hemorrhagic, non-hemorrhagic and mixed contusions after severe head injury and its effect on perilesional cerebral blood flow.
MedLine Citation:
PMID:  11450009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracerebral contusions can lead to regional ischemia caused by extensive release of excitotoxic aminoacids leading to increased cytotoxic brain edema and raised intracranial pressure. rCBF measurements might provide further information about the risk of ischemia within and around contusions. Therefore, the aim of the presented study was to compare the intra- and perilesional rCBF of hemorrhagic, non-hemorrhagic and mixed intracerebral contusions. In 44 patients, 60 stable Xenon-enhanced CT CBF-studies were performed (EtCO2 30 +/- 4 mmHg SD), initially 29 hours (39 studies) and subsequent 95 hours after injury (21 studies). All lesions were classified according to localization and lesion type using CT/MRI scans. The rCBF was calculated within and 1-cm adjacent to each lesion in CT-isodens brain. The rCBF within all contusions (n = 100) of 29 +/- 11 ml/100 g/min was significantly lower (p < 0.0001, Mann-Whitney U) compared to perilesional rCBF of 44 +/- 12 ml/100 g/min and intra/perilesional correlation was 0.4 (p < 0.0005). Hemorrhagic contusions showed an intra/perilesional rCBF of 31 +/- 11/44 +/- 13 ml/100 g/min (p < 0.005), non-hemorrhagic contusions 35 +/- 13/46 +/- 10 ml/100 g/min (p < 0.01). rCBF in mixed contusions (25 +/- 9/44 +/- 12 ml/100 g/min, p < 0.0001) was significantly lower compared to hemorrhagic and non-hemorrhagic contusions (p < 0.02). Intracontusional rCBF is significantly reduced to 29 +/- 11 ml/100 g/min but reduced below ischemic levels of 18 ml/100 g/min in only 16% of all contusions. Perilesional CBF in CT normal appearing brain closed to contusions is not critically reduced. Further differentiation of contusions demonstrates significantly lower rCBF in mixed contusions (defined by both hyper- and hypodense areas in the CT-scan) compared to hemorrhagic and non-hemorrhagic contusions. Mixed contusions may evolve from hemorrhagic contusions with secondary increased perilesional cytotoxic brain edema leading to reduced cerebral blood flow and altered brain metabolism. Therefore, the treatment of ICP might be individually modified by the measurement of intra- and pericontusional cerebral blood.
Authors:
B M Hoelper; M M Reinert; A Zauner; E Doppenberg; R Bullock
Related Documents :
19388329 - Biomechanical modeling of decompressive craniectomy in traumatic brain injury.
12657839 - Assessment of the lower limit for cerebral perfusion pressure in severe head injuries b...
12042919 - New non-invasive sonographic modality for intracranial pressure/volume monitoring.
12168299 - An estimated compliance index derived from intracranial pressure recording.
6811959 - The effects of molsidomine on intracranial pressure in anaesthetized dogs.
8659789 - Divergence of intracranial and central venous pressures in lightly anesthetized, trache...
22524589 - Haemodynamic stability and pulmonary shunt during spontaneous breathing and mechanical ...
7484039 - Qt interval of the ecg, heart rate and arterial pressure during anaesthetic induction: ...
7008619 - The effects of maxillary expansion using a quad-helix appliance during the deciduous an...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  76     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2000  
Date Detail:
Created Date:  2001-07-13     Completed Date:  2001-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Flow Velocity / physiology
Blood Volume / physiology
Brain / blood supply*
Brain Concussion / diagnosis,  physiopathology*
Brain Edema / diagnosis,  physiopathology*
Cerebral Cortex / blood supply,  injuries
Cerebral Hemorrhage / diagnosis,  physiopathology*
Cerebrovascular Circulation / physiology*
Female
Humans
Image Enhancement
Magnetic Resonance Imaging
Male
Reference Values
Regional Blood Flow / physiology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ICP and MABP following traumatic subarachnoid hemorrhage in the rat.
Next Document:  The synergistic effect of acute subdural hematoma combined with diffuse traumatic brain injury on br...