Document Detail

rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest.
MedLine Citation:
PMID:  12114004     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Our goal was to identify brain structures involved in anticipatory anxiety in panic disorder (PD) patients compared to control subjects. METHODS: Seventeen PD patients and 21 healthy control subjects were studied with H(2)(15)O positron emission tomography scan, before and after a pentagastrin challenge. RESULTS: During anticipatory anxiety we found hypoactivity in the precentral gyrus, the inferior frontal gyrus, the right amygdala, and the anterior insula in PD patients compared to control subjects. Hyperactivity in patients compared to control subjects was observed in the parahippocampal gyrus, the superior temporal lobe, the hypothalamus, the anterior cingulate gyrus, and the midbrain. After the challenge, the patients showed decreases compared to the control subjects in the precentral gyrus, the inferior frontal gyrus, and the anterior insula. Regions of increased activity in the patients compared to the control subjects were the parahippocampal gyrus, the superior temporal lobe, the anterior cingulate gyrus, and the midbrain. CONCLUSIONS: The pattern of regional cerebral blood flow activations and deactivations we observed both before and after the pentagastrin challenge was the same, although different in intensity. During anticipatory anxiety more voxels were (de)activated than during rest after the challenge.
Marjolein L Boshuisen; Gert J Ter Horst; Anne M J Paans; A A T Simone Reinders; Johan A den Boer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  52     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-12     Completed Date:  2002-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-35     Citation Subset:  IM    
Department of Psychiatry, Division of Biological Psychiatry, Graduate School of Behavioral and Cognitive Neurosciences, Groningen University Hospital, The Netherlands.
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MeSH Terms
Analysis of Variance
Anxiety / psychology,  radionuclide imaging
Blood Pressure / physiology
Cerebrovascular Circulation / physiology*
Heart Rate / physiology
Panic Disorder / physiopathology*,  psychology*,  radionuclide imaging
Pentagastrin / administration & dosage
Psychiatric Status Rating Scales
Rest / psychology
Tomography, Emission-Computed
Reg. No./Substance:

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