| On the question of body fluid volume or sodium status influencing renin release. | |
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MedLine Citation:
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PMID: 874867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The extent to which renin release is affected by simultaneous changes in body Na and body fluid volume was studied in six sheep. 2. The animals' water intake was restricted for 10-17 days after which they were offered solutions containing varying amounts of NaCl. 3. Plasma renin concentration (PRC) of water restricted sheep was 2-3 times normal. 4. The changes in PRC following drinking were inversely related to the amount of sodium consumed, Na excretion and plasma Na concentration. There was no correlation between the changes of PRC and of plasma volume in so far as the latter is reflected by alterations in plasma protein concentration. 5. We conclude that changes in renin release were related to the animals' handling of NA, and not to alterations in body fluid volume. 6. These findings are compatible with the proposition that renin release was mediated by a macula densa mechanism. |
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Authors:
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J R Blair-West; A H Brook; P A Simpson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 267 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-08-12 Completed Date: 1977-08-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 321-38 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / analysis Body Fluids / physiology* Drinking Female Renin / blood, secretion* Sheep Sodium / blood, metabolism*, urine |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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