| The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks. | |
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MedLine Citation:
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PMID: 9525595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) have evolved specific anatomic tropisms and site-dependent rates of reactivation. To determine whether reactivation rates depend on distinct abilities of HSV-1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains of each virus were studied in the guinea pig genital model. Following infection with equivalent titers of virus, the quantities of latent HSV-2 genomes and LATs were higher in lumbosacral ganglia, and HSV-2 infections recurred more frequently and lasted longer than HSV-1 infections. In contrast, if the inoculum of HSV-1 was 10 times that of HSV-2, the quantity of HSV-1 DNA and LATs increased correspondingly and HSV-1 infections were as likely to recur as those with HSV-2. The quantity of latent virus DNA correlates with and may be a major determinant of the site-specific patterns and rates of reactivation of HSV-1 and -2. |
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Authors:
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J A Lekstrom-Himes; L Pesnicak; S E Straus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of virology Volume: 72 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-04-17 Completed Date: 1998-04-17 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2760-4 Citation Subset: IM |
Affiliation:
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Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cercopithecus aethiops DNA, Viral / metabolism* Disease Models, Animal Female Guinea Pigs Herpes Genitalis / virology* Herpesvirus 1, Human / genetics, growth & development, physiology* Herpesvirus 2, Human / genetics, growth & development, physiology* Humans Phenotype Recurrence Vero Cells Virus Activation Virus Latency* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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