Document Detail

The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks.
MedLine Citation:
PMID:  9525595     Owner:  NLM     Status:  MEDLINE    
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) have evolved specific anatomic tropisms and site-dependent rates of reactivation. To determine whether reactivation rates depend on distinct abilities of HSV-1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains of each virus were studied in the guinea pig genital model. Following infection with equivalent titers of virus, the quantities of latent HSV-2 genomes and LATs were higher in lumbosacral ganglia, and HSV-2 infections recurred more frequently and lasted longer than HSV-1 infections. In contrast, if the inoculum of HSV-1 was 10 times that of HSV-2, the quantity of HSV-1 DNA and LATs increased correspondingly and HSV-1 infections were as likely to recur as those with HSV-2. The quantity of latent virus DNA correlates with and may be a major determinant of the site-specific patterns and rates of reactivation of HSV-1 and -2.
J A Lekstrom-Himes; L Pesnicak; S E Straus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  72     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-17     Completed Date:  1998-04-17     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2760-4     Citation Subset:  IM    
Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA.
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MeSH Terms
Acute Disease
Cercopithecus aethiops
DNA, Viral / metabolism*
Disease Models, Animal
Guinea Pigs
Herpes Genitalis / virology*
Herpesvirus 1, Human / genetics,  growth & development,  physiology*
Herpesvirus 2, Human / genetics,  growth & development,  physiology*
Vero Cells
Virus Activation
Virus Latency*
Reg. No./Substance:
0/DNA, Viral

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