Document Detail


A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study.
MedLine Citation:
PMID:  12765975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several genome-wide linkage scans have been carried out to identify quantitative trait loci for type 2 diabetes and related metabolic phenotypes. However, no previous linkage scans have focused on the response to exercise training of relevant metabolic traits. We performed a genome-wide linkage scan for baseline fasting glucose, insulin, and C-peptide and their responses to a 20-week exercise training program in nondiabetic white and black men and women from the HERITAGE Family Study. In SIBPAL linkage analyses, the maximum number of sibpairs available was 344 and 93 for baseline phenotypes and 300 and 72 for exercise training response phenotypes in whites and blacks, respectively. A total of 509 markers with an average spacing of 6.0 Mb were used. The strongest linkage was found for the changes in fasting insulin in response to exercise training with a marker in the leptin gene on 7q31 (empirical multipoint P = 0.0004) in whites. In blacks, the strongest linkage was observed for baseline fasting glucose on 12q13-q14 (empirical multipoint P = 0.0006). These regions harbor several potential candidate genes. The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle.
Authors:
Timo A Lakka; Tuomo Rankinen; S John Weisnagel; Yvon C Chagnon; Treva Rice; Arthur S Leon; James S Skinner; Jack H Wilmore; D C Rao; Claude Bouchard;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  52     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-26     Completed Date:  2003-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1583-7     Citation Subset:  AIM; IM    
Affiliation:
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Canada
Chromosome Mapping
Chromosomes, Human, Pair 7*
Cohort Studies
Diabetes Mellitus, Type 1 / genetics
European Continental Ancestry Group / genetics
Exercise / physiology*
Family
Female
Genetic Markers
Genome, Human
Humans
Insulin / blood*,  genetics
Linkage (Genetics)
Male
Physical Endurance / physiology
Quantitative Trait Loci*
United States
Grant Support
ID/Acronym/Agency:
1P41 RR 03655/RR/NCRR NIH HHS; HL 45670/HL/NHLBI NIH HHS; HL 47317/HL/NHLBI NIH HHS; HL 47321/HL/NHLBI NIH HHS; HL 47323/HL/NHLBI NIH HHS; HL 47327/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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