| A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study. | |
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MedLine Citation:
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PMID: 16818806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-adjusted systolic blood pressure is higher in males than females. Genetic factors may account for this sex-specific variation. To localize sex-specific quantitative trait loci (QTL) influencing blood pressure, we conducted a genome scan of systolic blood pressure, in males and females, separately and combined, and tested for aggregate and QTL-specific genotype-by-sex interaction in American Indian participants of the Strong Heart Family Study. Blood pressure was measured 3 times and the average of the last 2 measures was used for analyses. Systolic blood pressure was adjusted for age and antihypertensive treatment within study center. We performed variance component linkage analysis in the full sample and stratified by sex among 1168 females and 726 males. Marker allele frequencies were derived using maximum likelihood estimates based on all individuals, and multipoint identity-by-descent sharing was estimated using Loki. We detected suggestive evidence of a QTL influencing systolic blood pressure on chromosome 17 at 129 cM between markers D17S784 and D17S928 (logarithm of odds [LOD] = 2.4). This signal substantially improved when accounting for QTL-specific genotype-by-sex interaction (P = 0.04), because we observed an LOD score of 3.3 for systolic blood pressure in women on chromosome 17 at 136 cM. The magnitude of the linkage signal on chromosome 17q25.3 was slightly attenuated when participants taking antihypertensive medications were excluded, although suggestive evidence for linkage was still identified (LOD = 2.8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes. |
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Authors:
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Nora Franceschini; Jean W MacCluer; Harald H H Göring; Shelley A Cole; Kathryn M Rose; Laura Almasy; Vincent Diego; Sandra Laston; Elisa T Lee; Barbara V Howard; Lyle G Best; Richard R Fabsitz; Mary J Roman; Kari E North |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-07-03 |
Journal Detail:
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Title: Hypertension Volume: 48 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2006-09-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 266-70 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514-3628, USA. noraf@unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / genetics* Chromosome Mapping Chromosomes, Human, Pair 17 / genetics Female Genotype Humans Hypertension / epidemiology, genetics* Indians, North American / genetics* Lod Score Male Models, Genetic Phenotype Quantitative Trait Loci / genetics* Sex Distribution Systole United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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MH059490/MH/NIMH NIH HHS; U01 HL41642/HL/NHLBI NIH HHS; U01 HL41652/HL/NHLBI NIH HHS; U01 HL41654/HL/NHLBI NIH HHS; U01 HL65520/HL/NHLBI NIH HHS; U01 HL65521/HL/NHLBI NIH HHS |
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