Document Detail


A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study.
MedLine Citation:
PMID:  16818806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Age-adjusted systolic blood pressure is higher in males than females. Genetic factors may account for this sex-specific variation. To localize sex-specific quantitative trait loci (QTL) influencing blood pressure, we conducted a genome scan of systolic blood pressure, in males and females, separately and combined, and tested for aggregate and QTL-specific genotype-by-sex interaction in American Indian participants of the Strong Heart Family Study. Blood pressure was measured 3 times and the average of the last 2 measures was used for analyses. Systolic blood pressure was adjusted for age and antihypertensive treatment within study center. We performed variance component linkage analysis in the full sample and stratified by sex among 1168 females and 726 males. Marker allele frequencies were derived using maximum likelihood estimates based on all individuals, and multipoint identity-by-descent sharing was estimated using Loki. We detected suggestive evidence of a QTL influencing systolic blood pressure on chromosome 17 at 129 cM between markers D17S784 and D17S928 (logarithm of odds [LOD] = 2.4). This signal substantially improved when accounting for QTL-specific genotype-by-sex interaction (P = 0.04), because we observed an LOD score of 3.3 for systolic blood pressure in women on chromosome 17 at 136 cM. The magnitude of the linkage signal on chromosome 17q25.3 was slightly attenuated when participants taking antihypertensive medications were excluded, although suggestive evidence for linkage was still identified (LOD = 2.8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes.
Authors:
Nora Franceschini; Jean W MacCluer; Harald H H Göring; Shelley A Cole; Kathryn M Rose; Laura Almasy; Vincent Diego; Sandra Laston; Elisa T Lee; Barbara V Howard; Lyle G Best; Richard R Fabsitz; Mary J Roman; Kari E North
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-07-03
Journal Detail:
Title:  Hypertension     Volume:  48     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-09-05     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 17 / genetics
Female
Genotype
Humans
Hypertension / epidemiology,  genetics*
Indians, North American / genetics*
Lod Score
Male
Models, Genetic
Phenotype
Quantitative Trait Loci / genetics*
Sex Distribution
Systole
United States / epidemiology
Grant Support
ID/Acronym/Agency:
MH059490/MH/NIMH NIH HHS; U01 HL065520/HL/NHLBI NIH HHS; U01 HL41642/HL/NHLBI NIH HHS; U01 HL41652/HL/NHLBI NIH HHS; U01 HL41654/HL/NHLBI NIH HHS; U01 HL65520/HL/NHLBI NIH HHS; U01 HL65521/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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