Document Detail


A quantitative study of the facial nerve in mice prenatally exposed to ethanol.
MedLine Citation:
PMID:  12692402     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross-sectional area of the facial nerve of mice prenatally exposed to ethanol was significantly smaller than that of the control mice. There was no significant difference in the total number of myelinated axons or the mean axonal diameter between control and ethanol-exposed mice, but the mean diameter of myelinated fibers (axon + myelin sheath) and the thickness of myelin sheath were significantly decreased in the treated group. These results suggest that prenatal exposure to ethanol disturbs myelination of the motor root of the facial nerve and may cause permanent neurological effects.
Authors:
Suguru Komatsu; Yasuo Sasaki; Kohei Shiota
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital anomalies     Volume:  43     ISSN:  0914-3505     ISO Abbreviation:  Congenit Anom (Kyoto)     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-14     Completed Date:  2003-12-05     Revised Date:  2004-05-27    
Medline Journal Info:
Nlm Unique ID:  9306292     Medline TA:  Congenit Anom (Kyoto)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. komatsu@cac.med.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / drug effects
Disease Models, Animal
Ethanol / adverse effects*
Facial Nerve / drug effects*
Female
Fetal Alcohol Syndrome / etiology
Maternal Exposure*
Mice
Mice, Inbred ICR
Microscopy, Electron
Nerve Fibers, Myelinated / drug effects
Pregnancy
Pregnancy, Animal
Time Factors
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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