Document Detail

A quantitative study of the coincidence of blood vessels and A4 protein deposits in Alzheimer's disease.
MedLine Citation:
PMID:  1922919     Owner:  NLM     Status:  MEDLINE    
The spatial relationship between A4 protein deposits and blood vessels in the brains of 6 elderly cases of Alzheimer's disease has been investigated. Sections were taken from medial temporal cortex and were double immunostained for A4 protein and type IV collagen, the latter being employed as a marker of blood vessels. By comparing the observed area of vessel overlying A4 deposit with that predicted from the product of A4 deposit and blood vessel area fractions it is shown that, contrary to expectations, the likelihood of a vessel co-inciding with an A4 deposit is less than would be expected by chance. It would therefore appear that the previously described positive association between A4 deposits and blood vessels reflects the abundance of A4 and the high vascularity of the cortex rather than any specific correlation between the two features.
P J Luthert; J A Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  126     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  110-2     Citation Subset:  IM    
Department of Neuropathology, Institute of Psychiatry, London, U.K.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / metabolism*,  pathology
Amyloid beta-Protein / metabolism*
Blood Vessels / pathology
Brain / metabolism*,  pathology
Cerebrovascular Circulation*
Reg. No./Substance:
0/Amyloid beta-Protein

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