| A quantitative and morphometric study of tryptase-positive mast cells in cutaneous leprosy lesions. | |
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MedLine Citation:
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PMID: 18082641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While mast cells are known to induce differences in the matrix structures, microvascular patterns, and immune responses in a number of diseases, the possible role of mast cells in these same processes over the spectrum of leprosy has not yet been investigated. Thus, ascertaining the possible influence of mast cells in the outcome of the anti-leprosy response to Mycobacterium leprae is of major importance. In this study, 51 cutaneous biopsies of leprosy patients were stained with anti-tryptase antibody in order to quantify mast cells in leprosy lesions and compare the number and size of these cells in all the forms of leprosy. Biopsies were grouped according to an adapted Ridley-Jopling clinical-immunological classification (17 T, 17 B and 17 L). It was found that the L (lepromatous leprosy) group had the lowest dermal mast cell density values among the three groups studied. Furthermore, the average mast cell cross-sectional area was significantly higher in the L in comparison to the B (borderline-borderline) and T (tuberculoid) biopsies, suggesting mast cell functional differences within the groups. The higher mast cell density in the T and B groups was considered indirect evidence of the role of mast cells in the activated immune response to M. leprae infection. |
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Authors:
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Giselle de Oliveira Magalhães; Vânia da Costa Valentim; Mária Jose Dos Santos Pereira; José Augusto da Costa Nery; Ximena Illarramendi; Sérgio Luiz Gomes Antunes |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-05 |
Journal Detail:
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Title: Acta tropica Volume: 105 ISSN: 0001-706X ISO Abbreviation: Acta Trop. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-21 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370374 Medline TA: Acta Trop Country: Netherlands |
Other Details:
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Languages: eng Pagination: 62-6 Citation Subset: IM |
Affiliation:
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Leprosy Laboratory, Institute Oswaldo Cruz, FIOCRUZ, RJ, Brazil. gimagalhaes@ig.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biopsy Humans Leprosy, Lepromatous / immunology* Leprosy, Tuberculoid / immunology* Leukocyte Count Male Mast Cells / chemistry, cytology*, immunology* Middle Aged Skin / pathology Tryptases / analysis* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.59/Tryptases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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