Document Detail

A quantitative investigation of gonadal feminization by diethylstilboestrol of genetically male embryos of the quail Coturnix coturnix japonica.
MedLine Citation:
PMID:  7616493     Owner:  NLM     Status:  MEDLINE    
The effect of diethylstilboestrol on gonad development in quail embryos has been quantitatively analysed. Quail embryos at 4 days of incubation were treated with diethylstilboestrol (DES), using the egg dipping method. At 10 days of incubation, embryos were removed and killed by decapitation. Tissues were prepared for chromosome analysis, and the parts of the abdomen containing the gonads were prepared for serial sectioning and quantitative assessment. Left gonads of DES-treated male embryos resembled ovaries histologically, while their right gonads were markedly reduced in size. Right gonads of DES-treated female embryos were also further reduced by treatment with DES. There was no statistically significant effect by DES treatment on the size of left gonads, although the ratio of left compared with right gonadal volumes was highly significant. Since, in birds, the left embryonic gonad has ambisexual potential, while the potential of the right gonad is exclusively masculine, these results exemplify the adverse effect exerted by oestrogen on male sexual development in vertebrates.
F M Perrin; S Stacey; A M Burgess; U Mittwoch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  103     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Department of Anatomy, Queen Mary and Westfield College, London, UK.
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MeSH Terms
Bird Diseases / chemically induced*,  pathology
Coturnix / embryology*
Diethylstilbestrol / pharmacology*
Feminization / chemically induced*,  pathology
Ovary / drug effects,  pathology
Testis / drug effects*,  embryology,  pathology
Reg. No./Substance:

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