| The quantitative insulin sensitivity check index is not able to detect early metabolic alterations in young patients with polycystic ovarian syndrome. | |
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MedLine Citation:
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PMID: 20540677 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. To verify whether QUICKY is a suitable method for the identification of metabolic deterioration in normal weight patients affected by polycystic ovarian syndrome (PCOS). Design. Prospective clinical study. Patient(s). Seventy-nine PCOS normal weight adolescent subjects, 50 eumenorrheic, normal weight, non-hirsute controls matched for age and BMI. Method(s). Quantitative insulin sensitivity check index (QUICKY) and integrated secretory area under the curve of insulin values (I-AUC) during oral glucose tolerance test were calculated. Result(s). Seventy-nine PCOS and 50 controls were studied. Normal insulin sensitivity was defined as upper control 95th percentile by QUICKY values <0.31, I-AUC at 180 min < 16,645. When applying the calculated I-AUC cut-off, 41 PCOS were classified as normoinsulinemic and 38 as hyperinsulinemic, whereas using the calculated QUICKY cut-off, only 19 PCOS could be classified as insulin resistant (IR). Fifteen out of the 60 non-IR PCOS presented hyperinsulinemia; fasting glucose and insulin levels and QUICKY were not sufficient to identify these subjects. Thus, QUICKY displayed a low sensitivity (44%) and specificity (91%) in the diagnosis of the metabolic disorder disclosed by I-AUC. Conclusions. In young normal weight patients with PCOS the prevalence of early alterations of insulin metabolism are not detectable by QUICKY studies. |
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Authors:
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Stefano Angioni; Stefania Sanna; Roberta Magnini; Gian Benedetto Melis; Anna Maria Fulghesu |
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Publication Detail:
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Type: Journal Article Date: 2010-06-14 |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 27 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 468-74 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Cagliari, Cagliari, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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