| A quantitative histological assessment of cellular death, in relation to mitosis, in rat thymus during growth and age involution. | |
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MedLine Citation:
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PMID: 888748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rates of cellular proliferation and cellular death were investigated in the rat thymus during growth and involution. It was found that the percentage of dead cells gradually increased with age, whilst the rate of cell proliferation declined, indicating that a substantial proportion of lymphocytes that divide in the thymus also die there. It was also found that there exists a density-dependent distribution pattern of mitotic and dead cells and that this distribution pattern changed with age. It is suggested that this mechanism of density-dependent control of the thymus may be an important factor in the age involution of the thymus. |
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Authors:
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S M Hinsull; D Bellamy; A Franklin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Age and ageing Volume: 6 ISSN: 0002-0729 ISO Abbreviation: Age Ageing Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-09-22 Completed Date: 1977-09-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375655 Medline TA: Age Ageing Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Cell Count Cell Division Cell Movement Cell Survival Lymphocytes / physiology Male Rats Thymus Gland / cytology, physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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