Document Detail


A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24-36 weeks of gestation.
MedLine Citation:
PMID:  20537747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the plasma and serum maternal total antioxidant status, circulating levels of lipid peroxidation breakdown products (MDA), protein oxidation markers (AOPPs), myeloperoxidase (MPO) and lipid hydroperoxide (LHP) in preeclampsia, gestational diabetes mellitus (GDM) patients and compare them with noncomplicated normal pregnancies between 24 and 36 weeks of gestation.
STUDY DESIGN: 27 GDM, 27 preeclampsia and 29 noncomplicated singleton pregnancies were included. The blood samples were taken at the diagnosis of disease.
RESULTS: TAS was decreased in GDM and preeclampsia when compared to normal pregnancies. MDA levels were higher only in GDM group than normal pregnancies. AOPP levels were increased but MPO and LHP levels were not changed both in GDM and preeclampsia when compared to normal pregnancies.
CONCLUSIONS: We concluded that increased oxidative stress and reduction in antioxidant defense mechanisms may contribute to disease processes both in GDM and preeclampsia.
Authors:
Ozlem Karacay; Aylin Sepici-Dincel; Deniz Karcaaltincaba; Duygu Sahin; Serdar Yalvaç; Mesut Akyol; Omer Kandemir; Nilgün Altan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  89     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Ankara Etlik Maternity and Women's Health Teaching and Research Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism*
Diabetes, Gestational / blood*,  metabolism*
Female
Gestational Age
Humans
Lipid Peroxides / blood
Malondialdehyde / blood
Oxidative Stress / physiology*
Peroxidase / blood
Pre-Eclampsia / blood*,  metabolism*
Pregnancy
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Lipid Peroxides; 542-78-9/Malondialdehyde; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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