| The quantitative evaluation of online haemodiafiltration effect on skin hyperpigmentation. | |
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MedLine Citation:
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PMID: 20696681 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Skin pigmentation is a common problem for dialysis patients, but little is known about the factor responsible for the colour intensity. Middle-molecular-weight (MMW) substances have been suggested to be responsible for the skin colour. Several papers have reported that β(2)-microglobulin (β(2)-MG) correlates with the skin colour, and haemodiafiltration (HDF) is effective to reduce the skin hyperpigmentation. However, a quantitative skin colour follow-up on patients treated with online haemodiafiltration (online HDF) has not been performed. METHODS: Sixty-one patients were enrolled in this study. Quantification of skin colour was done using a reflected light colorimeter. Among them, 51 patients were under haemodialysis (HD), and the other 10 patients were under online HDF. Follow-ups to estimate the skin colour change were performed for 6 months. Among 10 patients under online HDF, four patients were also investigated by crossover way between HD and online HDF. RESULTS: Compared with controls, patients treated with HD had darker skin. The colour value was well correlated with age, haematocrit, sex, diabetes and β(2)-MG but not with Kt/V. The skin colour got worse under HD treatment as well as the values of β(2)-MG, but online HDF improved the hyperpigmentation and the β(2)-MG values. CONCLUSIONS: Our data show the effectiveness of online HDF on skin colour and suggest that HD patients' skin colour can be improved by modality change. |
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Authors:
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Masanori Shibata; Kojiro Nagai; Kazumasa Usami; Hideo Tawada; Shinkichi Taniguchi |
Publication Detail:
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Type: Journal Article Date: 2010-08-09 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 988-92 Citation Subset: IM |
Affiliation:
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Kojiro Nagai; E-mail: knagai@clin.med.tokushima-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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