Document Detail


A qualitative model for aggregation and diffusion of [Formula: see text]-amyloid in Alzheimer's disease.
MedLine Citation:
PMID:  23014767     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this paper we present a mathematical model for the aggregation and diffusion of A[Formula: see text] amyloid in the brain affected by Alzheimer's disease, at the early stage of the disease. The model is based on a classical discrete Smoluchowski aggregation equation modified to take diffusion into account. We also describe a numerical scheme and discuss the results of the simulations in the light of the recent biomedical literature.
Authors:
Yves Achdou; Bruno Franchi; Norina Marcello; Maria Carla Tesi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Journal of mathematical biology     Volume:  -     ISSN:  1432-1416     ISO Abbreviation:  J Math Biol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502105     Medline TA:  J Math Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratoire Jacques-Louis Lions, Sorbonne Paris Cité, Univ. Paris Diderot, UPMC, CNRS, UMR 7598, 75205 , Paris, France, achdou@math.jussieu.fr.
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