| q-Space diffusion of myelin-deficient spinal cords. | |
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MedLine Citation:
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PMID: 17969109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The apparent water diffusion anisotropy in white matter (WM) of excised spinal cords of myelin-deficient (md) rats and their age-matched controls was studied by high-b-value q-space diffusion MRS and MRI at different diffusion times. Non-monoexponential signal decay was observed at long diffusion times. The mean displacements in the md spinal cords were found to be higher than those of the controls. The apparent anisotropy (AA) of the fast-diffusing component was found to decrease more dramatically with the increase in diffusion time for the md spinal cords as compared with controls, whereas the AA of the slow-diffusing component in the controls was found to increase with the increase in diffusion time while that of the md cords decreased with the increase in diffusion time. When diffusion MRI was performed, similar diffusion anisotropy was extracted for the md and control spinal cords at diffusion times of 22 and 50 ms. Only at a diffusion time of about 200 ms was a significant difference obtained in the AA of the two groups. This originates from the much smaller increase in the mean displacement perpendicular to the fiber direction in the control group vs. the md group when the diffusion time was increased. |
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Authors:
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I E Biton; I D Duncan; Y Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 58 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 993-1000 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley-Liss, Inc. |
Affiliation:
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School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diffusion Magnetic Resonance Imaging Myelin Sheath / metabolism* Rats Spinal Cord / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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