| The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis. | |
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MedLine Citation:
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PMID: 20150327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heterotrimeric G proteins transduce the signals of the largest family of membrane receptors (G protein-coupled receptors, GPCRs) hence triggering the activation of a wide variety of physiological responses. G15 is a G protein characterized by a number of functional peculiarities that make its signaling exceptional: 1) it can couple a variety of Gs-, Gi/o-, and Gq-linked receptors to phospholipase C activation; 2) relatively to other G proteins, it is poorly affected by beta-arrestin-dependent desensitization, the general mechanism that regulates GPCR function and 3) at the protein level, its expression is only detected in highly specific cell types (hematopoietic and epithelial cells). G15 alpha-subunit displays unique structural and biochemical properties, and is phylogenetically the most recent and divergent component of the Galphaq/11 subfamily. All these aspects shed a mysterious light on G15 biological role, which remains substantially elusive. Thus, far, G15 signaling has been analyzed in the context of hematopoiesis. Here, we highlight observations supporting the view that G15 functions may extend further beyond the immune system. In addition, we describe puzzling aspects of G15 signaling that offer a novel perspective in the understanding of its physiological role. |
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Authors:
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Flavia Giannone; Giorgio Malpeli; Veronica Lisi; Silvia Grasso; Priyanka Shukla; Dunia Ramarli; Silvia Sartoris; Vladia Monsurr?; Mauro Krampera; Eliana Amato; Giuseppe Tridente; Marco Colombatti; Marco Parenti; Giulio Innamorati |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-02-11 |
Journal Detail:
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Title: Journal of molecular endocrinology Volume: 44 ISSN: 1479-6813 ISO Abbreviation: J. Mol. Endocrinol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902617 Medline TA: J Mol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 259-69 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, University of Milano-Bicocca, Monza 20052, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals GTP-Binding Protein alpha Subunits / genetics, physiology* Hematopoiesis Humans Phylogeny Receptors, G-Protein-Coupled / metabolism Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/GTP-Binding Protein alpha Subunits; 0/Receptors, G-Protein-Coupled |
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