Document Detail


The putative R1 protein of Streptococcus agalactiae as serotype marker and target of protective antibodies.
MedLine Citation:
PMID:  11846725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The streptococcal R1 protein was studied by means of anti-R1 antibodies prepared by appropriate cross-absorption of rabbit antiserum raised against the group B streptococcal (GBS) strain ATCC 12403 (D136C), serotype III/R1. The protein was a ladder-forming antigen according to banding patterns in immunoblotting, similar to several other GBS proteins, and was susceptible to digestion by both pepsin and trypsin. Antibody-based testing revealed that 10% of Norwegian GBS isolates expressed the R1 protein, most frequently capsular antigen type V strains (72%) and less frequently type III strains (3%). None of 132 GBS strains from Zimbabwe, including 39 type V strains, expressed the R1 protein. R1-specific rabbit antibodies showed protective activity in mice challenged with a GBS type V/R1 strain. The results show that the R1 protein is an important GBS serotype marker in strains from certain geographical areas, notably for the subtyping of capsular type V strains, and that this protein is a target of protective antibodies.
Authors:
S R Moyo; J A Maeland; R V Lyng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  109     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  842-8     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, University of Zimbabwe Medical School, Harare, Zimbabwe.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / immunology*
Bacterial Proteins / immunology*
Biological Markers
Cross Reactions
Mice
Rabbits
Serotyping
Streptococcus agalactiae / classification,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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