| The putative R1 protein of Streptococcus agalactiae as serotype marker and target of protective antibodies. | |
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MedLine Citation:
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PMID: 11846725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The streptococcal R1 protein was studied by means of anti-R1 antibodies prepared by appropriate cross-absorption of rabbit antiserum raised against the group B streptococcal (GBS) strain ATCC 12403 (D136C), serotype III/R1. The protein was a ladder-forming antigen according to banding patterns in immunoblotting, similar to several other GBS proteins, and was susceptible to digestion by both pepsin and trypsin. Antibody-based testing revealed that 10% of Norwegian GBS isolates expressed the R1 protein, most frequently capsular antigen type V strains (72%) and less frequently type III strains (3%). None of 132 GBS strains from Zimbabwe, including 39 type V strains, expressed the R1 protein. R1-specific rabbit antibodies showed protective activity in mice challenged with a GBS type V/R1 strain. The results show that the R1 protein is an important GBS serotype marker in strains from certain geographical areas, notably for the subtyping of capsular type V strains, and that this protein is a target of protective antibodies. |
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Authors:
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S R Moyo; J A Maeland; R V Lyng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 109 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-02-15 Completed Date: 2002-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 842-8 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University of Zimbabwe Medical School, Harare, Zimbabwe. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / immunology* Bacterial Proteins / immunology* Biological Markers Cross Reactions Mice Rabbits Serotyping Streptococcus agalactiae / classification, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Biological Markers |
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