Document Detail

The purine nucleotide cycle in skeletal muscle.
MedLine Citation:
PMID:  658470     Owner:  NLM     Status:  MEDLINE    
The following evidence demonstrates that ammonia production in muscle occurs via the reactions of the purine nucleotide cycle: i) Extracts of cytosol which lack glutamine dehydrogenase produce ammonia under conditions that mimic muscle doing work. In such extracts a member of the purine nucleotide cycle (AMP, IMP, or adenylosuccinate) must be present in order that ammonia production can take place, ii) Perfused hindleg of rat or hindleg in situ produces ammonia during exercise, and there is a concomitant production of IMP and adenylosuccinate. Exercise causes a decrease in the contents of glutamate, aspartate, and glutamine and an increase in the content of alanine of perfused hindleg of rat. However, output of alanine does not change or is diminished during exercise. Glutamine output is diminished by exercise. Epinephrine increases the output and tissue content of ammonia and glutamine. It decreases the output and content of alanine, and it decreases the contents of aspartate and glutamate.
J M Lowenstein; M N Goodman
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Federation proceedings     Volume:  37     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2308-12     Citation Subset:  IM; S    
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MeSH Terms
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / analogs & derivatives,  metabolism
Ammonia / metabolism
Epinephrine / pharmacology
Inosine Monophosphate / metabolism
Lactates / metabolism
Muscles / metabolism*
Phosphocreatine / metabolism
Physical Exertion
Purine Nucleotides / metabolism*
Succinates / metabolism
Reg. No./Substance:
0/Lactates; 0/Purine Nucleotides; 0/Succinates; 131-99-7/Inosine Monophosphate; 51-43-4/Epinephrine; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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