Document Detail

The pulsatile component of blood pressure: its role in the pathogenesis of atherosclerosis.
MedLine Citation:
PMID:  17852092     Owner:  NLM     Status:  MEDLINE    
Pulse pressure (PP) is traditionally believed to increase cardiovascular risk because of an increase in afterload leading to left ventricular hypertrophy. It has also been emphasized that low diastolic blood pressure, being in part responsible for high PP, leads to an impairment of myocardial perfusion with all its adverse consequences. More recently, however, a direct role of pulsatile blood pressure changes in the pathogenesis of atherosclerosis and its complications has become better known. Experimental studies indicate that there is a cause-and-effect type of relationship between the pulsatile component of blood pressure and atherosclerotic process. A significant relationship between the parameters of the pulsatile blood pressure component and the extent of coronary atherosclerosis was also demonstrated. Currently the presence of a bidirectional link between atherosclerosis and PP is commonly postulated, meaning that an increased PP may be both a cause and an effect of atherosclerosis. This may result in a vicious circle wherein the pulsatile blood pressure component induces/enhances the development of atherosclerosis, which in its turn reduces the arterial compliance and enhances pulse wave reflection, thereby leading to an increase in PP. Currently new drug classes are being investigated, which might reduce the pulsatile blood pressure component without changing mean blood pressure level. Their clinical usefulness should become known over the next few years.
Piotr Jankowski; Grzegorz Bilo; Kalina Kawecka-Jaszcz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood pressure     Volume:  16     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-19     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  238-45     Citation Subset:  IM    
I Department of Cardiology and Hypertension, Collegium Medicum Jagiellonian University, Kraków, Poland.
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MeSH Terms
Atherosclerosis / physiopathology*
Blood Pressure / physiology*
Hypertension / complications
Pulsatile Flow / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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