Document Detail


The pulmonary vascular response to the sustained activation of the muscle metaboreflex in man.
MedLine Citation:
PMID:  18218964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pulmonary circulation is influenced by the autonomic nervous system, yet whether this is physiologically important during exercise in man is not known. The aim of this study was to assess the pulmonary vascular response to sympathoexcitation induced by the maintained activation of the muscle metaboreflex in the postexercise period. Nine healthy subjects performed isometric handgrip exercise at 50% of their maximal voluntary contraction force for 2 min. Exercise was followed by circulatory occlusion so as to maintain the muscle metaboreflex activated for 2 min (postexercise circulatory occlusion; PECO). Blood pressure measurements and echocardiographically determined estimates of systolic pulmonary artery pressure (SPAP) and cardiac output were obtained at various intervals throughout the two protocols. Compared with baseline values, elevations in SPAP (by 20.06 +/- 2.08%), cardiac output (by 36.04 +/- 4.97%) and mean arterial pressure (MAP; by 25.62 +/- 3.54%) were noted during isometric exercise (means +/- s.e.m., all P < 0.05). Increases in SPAP and MAP persisted during PECO (all P < 0.05), whereas cardiac output returned to resting levels. Our findings suggest that the sympathoexcitation induced by isometric exercise affects the pulmonary circulation, possibly by inducing vasoconstriction and/or stiffening the large conduit arteries. The exaggerated activation of the sympathetic nervous system that has been evidenced in cardiopulmonary patients could therefore be implicated in their abnormal pulmonary haemodynamic responses and intolerance of exercise.
Authors:
Christos K Lykidis; Michael J White; George M Balanos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  93     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Affiliation:
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Blood Pressure / physiology
Cardiac Output / physiology
Echocardiography
Exercise / physiology
Female
Hand Strength / physiology
Heart Rate / physiology
Humans
Male
Muscle, Skeletal / metabolism*,  physiology*
Pulmonary Artery / physiology
Pulmonary Circulation / physiology*
Reflex / physiology
Respiratory Mechanics / physiology
Stroke Volume / physiology
Sympathetic Nervous System / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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