Document Detail

The pulmonary vascular response to combined activation of the muscle metaboreflex and mechanoreflex.
MedLine Citation:
PMID:  23064507     Owner:  NLM     Status:  Publisher    
Muscle metabo- and mechanoreflexes are known to influence systemic cardiovascular responses to exercise. Whether interplay between these reflexes is operant in the control of the pulmonary vascular response to exercise is unknown. The aim of this study was to assess the pulmonary vascular response to the combined activation of the two muscle reflexes. Nine healthy subjects performed a bout of isometric calf plantarflexion exercise during local circulatory occlusion, which was continued for 9 minutes post-exercise (PECO). At 5 minutes into PECO the calf muscle was passively stretched for 180 s. A control (no exercise) protocol was also undertaken. Heart rate and blood pressure measurements and echocardiographically determined estimates of systolic pulmonary artery pressure (SPAP) and cardiac output Q , were obtained at intervals throughout the two protocols. Elevations in SPAP (22.51±2.61%), Q (26.92±2.99%) and mean arterial pressure MAP (15.38±2.29%) were noted during isometric exercise as compared to baseline (All P<0.05). Increases in SPAP and MAP persisted during PECO (All P<0.05), whereas Q returned to resting levels. These increases in MAP and SPAP were sustained during stretch which significantly elevated Q (All P<0.05). These data suggest that activation of the muscle mechanoreflex attenuated the increases in pulmonary vascular resistance caused by metaboreflex activation. This finding has important implications for the regulation of pulmonary haemodynamics during human exercise.
Michael J White; Christos K Lykidis; George M Balanos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Birmingham.
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