|A pulmonary nodule due to pulmonary infarction diagnosed by video-assisted thoracoscopy.|
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|PMID: 19718413 Owner: NLM Status: MEDLINE|
|We report a pulmonary infarction in 68-year-old man who was referred for an asymptomatic pulmonary nodule in chest radiography. Computed tomography (CT), positron emission tomography (PET), and transthoracic needle aspiration suggested suspicion for malignancy. Video-assisted thoracoscopic surgery (VATS) was performed for histologic diagnosis. Our case is a pulmonary nodule due to pulmonary infarction diagnosed by VATS in Korea.|
|Jae Hwa Cho; Joung Taek Kim; Lucia Kim; Kyung Hee Lee; Jeong Seon Ryu; Seung Min Kwak; Hong Lyeol Lee|
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|Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-19|
|Title: Yonsei medical journal Volume: 50 ISSN: 1976-2437 ISO Abbreviation: Yonsei Med. J. Publication Date: 2009 Aug|
|Created Date: 2009-08-31 Completed Date: 2010-03-03 Revised Date: 2013-05-23|
Medline Journal Info:
|Nlm Unique ID: 0414003 Medline TA: Yonsei Med J Country: Korea (South)|
|Languages: eng Pagination: 591-3 Citation Subset: IM|
|Department of Internal Medicine, School of Medicine, Inha University, Incheon, Korea. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Pulmonary Infarction / complications*
Solitary Pulmonary Nodule / etiology*
Thoracic Surgery, Video-Assisted
Journal ID (nlm-ta): Yonsei Med J
Journal ID (publisher-id): YMJ
Publisher: Yonsei University College of Medicine
? Copyright: Yonsei University College of Medicine 2009
Received Day: 13 Month: 6 Year: 2007
Revision Received Day: 04 Month: 1 Year: 2008
Accepted Day: 04 Month: 1 Year: 2008
Print publication date: Day: 31 Month: 8 Year: 2009
Electronic publication date: Day: 19 Month: 8 Year: 2009
Volume: 50 Issue: 4
First Page: 591 Last Page: 593
PubMed Id: 19718413
|A Pulmonary Nodule due to Pulmonary Infarction Diagnosed by Video-Assisted Thoracoscopy|
|Jae Hwa Cho1|
|Joung Taek Kim2|
|Kyung Hee Lee4|
|Jeong Seon Ryu1|
|Seung Min Kwak1|
|Hong Lyeol Lee1|
1Department of Internal Medicine, School of Medicine, Inha University, Incheon, Korea.
2Department of Thoracic Surgery, School of Medicine, Inha University, Incheon, Korea.
3Department of Pathology, School of Medicine, Inha University, Incheon, Korea.
4Department of Radiology, School of Medicine, Inha University, Incheon, Korea.
Corresponding author: Dr. Jae Hwa Cho, Department of Internal Medicine, School of Medicine, Inha University, 7-206 Sinheung-dong 3-ga, Jung-gu, Incheon 400-103, Korea. Tel: 82-32-890-3490, Fax: 82-32-882-6578, email@example.com
Pulmonary infarctions typically present as wedge-shaped peripheral parenchymal opacities on computed tomography (CT).1 Rarely, however, they present as pulmonary nodules or mass.2,3 An undiagnosed pulmonary nodule or mass should be evaluated by CT, positron emission tomography (PET) scan, and lung biopsy to confirm malignancy.4
We report herein a case of pulmonary infarction presenting an asymptomatic pulmonary nodule which was initially suspected of malignancy and was finally confirmed by video-assisted thoracoscopic surgery (VATS).
A 68-year-old man was referred for an undetermined pulmonary nodule which was revealed by a health check up. He had had hypertension for 10 years and was taking antihypertensive medications. He was a 30 pack-year ex-smoker. On admission, his blood pressure was 120 / 70 mmHg, pulse rate 76/minute, respiratory rate 18/minute, and body temperature 36.6?. He did not complain any chest symptoms. On physical examination, there were no remarkable findings. Laboratory tests showed no abnormal findings. Sputum examinations for acid-fast bacilli were negative and for cytology were negative for malignancy.
Chest radiography revealed a solitary pulmonary nodule (SPN) in the right upper lobe. Chest CT scan showed a solitary parenchymal opacity with subpleural base, convex borders and focal low attenuation area within density, and 3?2 cm in size in the right upper lobe of the lung. The margin was slightly lobulated, and enhanced by contrast media.
PET-CT scan revealed an abnormal hypermetabolic nodule with maximal standard uptake value of 1.0. CT-guided transthoracic needle aspiration was done for further evaluation of a pulmonary nodule. Cytology showed a few atypical cells and reported suspicion for malignancy. Lung perfusion scan revealed focal perfusion defects in the right upper lobe. To confirm malignancy before radical lung resection, wedge resection was performed by VATS. On gross section, there was a relatively well demarcated mass, measuring 2.3?2.0 cm. The cut surface of mass was yellow, tan colored, necrotic and granular. No thrombi and inflammations around vessels were seen. The doppler ultrasound study of lower extremities revealed no evidence of deep vein thrombosis.
An asymptomatic pulmonary nodule in an elderly patient with 30 pack-year smoking should be evaluated by CT, PET-CT scan and lung aspiration cytology. These studies suspected lung malignancy, but wedge resection via VATS revealed localized pulmonary infarction.
Pulmonary infarctions result from pulmonary thromboembolism, heart failure, vasculitis, infection, and malignancy.1,5 In one study, undiagnosed SPNs or masses were found in 16 patients among 43 patients with pulmonary infarctions diagnosed by surgical lung biopsy.2 Six patients had features suggestive for malignancy on CT scan, PET scan or transthoracic needle aspiration. Fifty-percent of patients received oral anticoagulant therapy, 2 for chronic atrial fibrillation and 1 for deep vein thrombosis.2 In our patient, there were no predisposing factors of venous thromboembolism and no chest symptoms.
Radiologically, pulmonary infarctions appear parenchymal density with broad pleural base, convex borders, linear strands from apex of the infarct toward hilum, truncated apex, broad pleural base, and low attenuation areas within the lesion.6 Pulmonary infarctions could be suggested by peripheral parenchymal opacities with characteristic findings on CT scan. PET-CT scan is usually used in initial and follow up staging of lung cancer. False-positive results can occur in acute inflammation or infectious conditions. Pulmonary embolisms have abnormally hypermetabolic nodules and small occult infarctions also have hypermetabolic nodules in the peripheral lung.7
The transthoracic needle aspiration cytology revealed false-positive results. Histologically, atypical reactive alveolar lining type II cells and metaplastic cells near the infarction can result in this false-positive cytology results.8,9
In cases of the peripheral lung nodules in subpleural regions, the possibility of pulmonary infarctions should be considered, even in the absence of evidence of venous thromboembolism. VATS should be performed to confirm the nature of nodules.
The authors have no financial conflicts of interest.
This study was supported by INHA University Research Grant (INHA).
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Keywords: Solitary pulmonary nodule, pulmonary infarction, video-assist thoracoscopic surgery.
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