Document Detail

The pulmonary circulation and exercise responses in the elderly.
MedLine Citation:
PMID:  20941654     Owner:  NLM     Status:  MEDLINE    
Aging is associated with a progressive deterioration in the structure and function of the pulmonary circulation. Remodeling of the pulmonary vasculature occurs from maturity to senescence that is characterized by an increase in pulmonary vascular stiffness, pulmonary vascular pressures, and pulmonary vascular resistance along with increased heterogeneity of alveolar ventilation and pulmonary perfusion and decreased pulmonary capillary blood volume and membrane diffusing capacity that is consistent with a reduction in alveolar-capillary surface area. In theory, the aforementioned age-related changes in the pulmonary circulation may conspire to make elderly individuals more susceptible to gas exchange abnormalities during exercise. However, despite the erosion in ventilatory reserve with aging, the healthy older adult appears able to maintain alveolar ventilation at a level that allows maintenance of arterial blood gases within normal limits, even during heavy exercise. This ability to maintain adequate gas exchange likely occurs because age-related reductions in the maximal metabolic demand of exercise occur at a rate equal to or greater than the rate of deterioration in ventilatory reserve. A more prominent aspect of aging is the loss of lung elastic recoil that is associated with a modest reduction in the expiratory boundary of the maximal flow-volume envelope. This in turn increases the severity of expiratory airflow limitation and induces dynamic lung hyperinflation during exercise. The consequences of this age-associated decrease in elastic recoil on the pulmonary circulation are speculative, but an age-associated decline in elastic recoil may influence pulmonary vascular resistance and cardiac output, in addition to its impact on the work and oxygen cost of breathing.
Bryan J Taylor; Bruce D Johnson
Related Documents :
7355894 - Alteration of pulmonary function in intravenous drug abusers. prevalence, severity, and...
5387024 - Mechanism of stimulation of type j pulmonary receptors.
16269434 - Transvascular fluid flux from the pulmonary vasculature at rest and during exercise in ...
19875684 - Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive...
15220204 - Effects of low and moderate antecedent exercise on counterregulatory responses to subse...
21811184 - A flatter proximal trochlear groove is associated with patella cartilage loss.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-12
Journal Detail:
Title:  Seminars in respiratory and critical care medicine     Volume:  31     ISSN:  1098-9048     ISO Abbreviation:  Semin Respir Crit Care Med     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-02-14     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9431858     Medline TA:  Semin Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-38     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / physiology
Exercise / physiology*
Exercise Tolerance / physiology
Heart Failure / etiology
Lung / physiology*
Pulmonary Circulation / physiology*
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structural and physiological age-associated changes in aging lungs.
Next Document:  Susceptibility of the aging lung to environmental injury.