Document Detail


A prototype device for non-invasive continuous monitoring of intracerebral hemorrhage.
MedLine Citation:
PMID:  23261653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prototype for a non-invasive, real-time, monitoring device was developed to detect changes in the brain secondary to disease or injury such as intracerebral hemorrhage (ICH). The eventual goal is a non-invasive, real time sensor that can alert the clinician to alterations in the comatose patient's brain resulting from hemorrhage, seizure or stroke. In this work, a 400 MHz electromagnetic (EM) signal was transmitted with an antenna (T), incident on a 'brain gel' in vitro ICH model, and received by a receiving (R) antenna. Changes in the received signal were found to be induced by the presence of blood. The received power (P(R)) was found to be a linear function of the cross sectional area of blood, as measured normal to the incident wave. In addition, the sensor was able to detect as little as 1 mL of blood in this 1000 mL in vitro model.
Authors:
Joseph J Korfhagen; Madhuvanthi A Kandadai; Joseph F Clark; Opeolu Adeoye; George J Shaw
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-20
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  213     ISSN:  1872-678X     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-07-25     Revised Date:  2014-10-17    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  132-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Anatomy, Cross-Sectional
Animals
Cerebral Hemorrhage / physiopathology*
Cerebrospinal Fluid / chemistry
Electric Conductivity
Electromagnetic Fields
Gels
Humans
Linear Models
Monitoring, Physiologic / instrumentation*,  methods*
Phantoms, Imaging
Radio Waves
Temporal Bone / physiology
Grant Support
ID/Acronym/Agency:
U54 EB007954/EB/NIBIB NIH HHS; UL1 TR000077/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Gels
Comments/Corrections

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