Document Detail


The protooncogene c-myc is an essential regulator of neural crest formation in xenopus.
MedLine Citation:
PMID:  12791268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neural crest, a population of multipotent progenitor cells, is a defining feature of vertebrate embryos. Neural crest precursor cells arise at the neural plate border in response to inductive signals, but much remains to be learned about the molecular mechanisms underlying their induction. Here we show that the protooncogene c-Myc is an essential early regulator of neural crest cell formation in Xenopus. c-myc is localized at the neural plate border prior to the expression of early neural crest markers, such as slug. A morpholino-mediated "knockdown" of c-Myc protein results in the absence of neural crest precursor cells and a resultant loss of neural crest derivatives. These effects are not dependent upon changes in cell proliferation or cell death. Instead, our findings reveal an important and unexpected role for c-Myc in the specification of cell fates in the early ectoderm.
Authors:
Amy Bellmeyer; Jessica Krase; Julie Lindgren; Carole LaBonne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  4     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-06     Completed Date:  2003-07-25     Revised Date:  2013-06-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  827-39     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Biological Markers
Cell Division
Ectoderm / cytology,  physiology
Embryo, Nonmammalian / embryology
Embryonic Induction
Gene Expression Regulation, Developmental*
Genes, myc / physiology*
Neural Crest / cytology,  embryology*,  metabolism
Oligonucleotides, Antisense / metabolism
Proto-Oncogene Proteins c-myc / metabolism
Transcription Factors / metabolism
Xenopus
Grant Support
ID/Acronym/Agency:
R01 CA114058/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Oligonucleotides, Antisense; 0/Proto-Oncogene Proteins c-myc; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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