Document Detail

A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages.
MedLine Citation:
PMID:  19616977     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study to evaluate the hippocampal, frontal and thalamic lobe functions in the early stage of the juvenile absence epilepsy (JAE) by magnetic resonance proton spectroscopy (MRS). METHOD: Fourteen patients with juvenile absence epilepsy with typical absence seizures and 10 healthy volunteer controls were included in this study. The diagnosis of the patients was in accordance with EEG findings and seizure semiology. All patients had minimum twice EEG recordings and all had typical 3-Hz generalized spike and slow-wave discharges at least on one EEG. All patients had bilateral MRS of frontal, thalamic and hippocampal regions and NAA, NAA/Cr, NAA/Cho, NAA/Cho+Cr levels were detected. RESULTS: The mean age was 14.9+/-2.05 and 14.5+/-1.7 of the JAE patients and control subjects, respectively. Mean seizure onset duration were 2.3+/-0.9 years. In patient group the frontal, thalamic and hippocampal NAA/Cr ratios were 1.65, 1.78, 1.47 in right and 1.75, 1.90, 1.42 in left, respectively. While in the control group NAA/Cr ratios were 1.64, 2.42, 1.57 in right and 1.83, 2.44, 1.47 in left, respectively. There weren't any difference in frontal and hippocampal regions, but the bilateral thalamic NAA, NAA/Cr ratios of the patients were significantly lower than control group even in early stages of the disease. CONCLUSION: The observed reductions in NAA levels and NAA/Cr ratios of bilateral thalamic regions are consistent with epilepsy related excitoxicity as a possible underlying mechanism even in early stage of JAE. However, we believe that to generalize the results of our study a prospective multicenter study is required.
Sibel Canbaz Kabay; Oguzhan Guven Gumustas; Handan Ozisik Karaman; Hilmi Ozden; Oguz Erdinc
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Publication Detail:
Type:  Journal Article     Date:  2009-07-18
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  14     ISSN:  1532-2130     ISO Abbreviation:  Eur. J. Paediatr. Neurol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  224-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 European Paediatric Neurology Society. All rights reserved.
Dumlupinar University, Faculty of Medicine, Department of Neurology, Tavsanli Yolu, 43100 Kutahya, Turkey.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  analysis,  metabolism
Brain / anatomy & histology,  metabolism,  physiopathology*
Choline / analysis,  metabolism
Creatine / analysis,  metabolism
Disease Progression
Down-Regulation / physiology
Epilepsy, Absence / diagnosis*,  metabolism,  physiopathology*
Frontal Lobe / metabolism,  physiopathology
Functional Laterality / physiology
Hippocampus / metabolism,  physiopathology
Magnetic Resonance Spectroscopy / methods*
Membrane Potentials / physiology
Neurotoxins / metabolism
Predictive Value of Tests
Thalamus / metabolism,  physiopathology
Reg. No./Substance:
0/Neurotoxins; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate

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