| A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle. | |
| | |
MedLine Citation:
|
PMID: 21424576 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP) diet on both cognitive performance and corresponding biochemical parameters. A randomised intervention study was conducted with 23 healthy males (aged 19-31 years) to investigate the effects of a usual (UP) versus a HP diet on cognitive function and on the platelet proteome a well-established model for neurons. The study individuals were assigned to either a UP diet (15% energy) or a HP diet (30% energy) for 3 weeks with controlled intake of food and beverages. Blood samples were taken along with measurements of cognitive functions at the beginning and at the end of the intervention period. Among 908 reproducibly studied platelet proteins only the level of monoamine oxidase B (MaoB), a neurotransmitter degrading enzyme, decreased by 26% significantly (adjusted P value < 0.05) due to the HP diet. In addition, we found a correlation (r = 0.477; P < 0.02) between the decrease of MaoB expression and the shortened reaction time (cognitive function) which is in accordance with reports that dementia patients show increased MaoB activity. Plasma vitamin B(12) concentration was increased by the HP diet and correlates inversely with platelet MaoB expression (r = -0.35; P < 0.02). Healthy young males on a HP diet showed improved cognitive function and counteract well-known dementia biomarkers such as platelet MaoB and components of the methylation cycle such as vitamin B(12) and homocysteine. |
| | |
Authors:
|
Maria Zellner; Rita Babeluk; Lene H Jakobsen; Christopher Gerner; Ellen Umlauf; Ivo Volf; Erich Roth; Jens Kondrup |
Related Documents
:
|
19413706 - Reflections from a systematic review of dietary energy density and weight gain: is the ... 8412776 - Energy metabolism in response to overfeeding in young adult men. 20171846 - Energy expenditure and estimated caloric intake in asthmatic adolescents with excess bo... 6483726 - Responses to dietary self selection and calories in liquid form by weight selected line... 15331386 - Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity... 9569516 - Measurement and prediction of total body fat. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-20 |
Journal Detail:
|
Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: - ISSN: 1435-1463 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria, maria.zellner@meduniwien.ac.at. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two-dimensional linear-combination model fitting of magnetic resonance spectra to define the macromo...
Next Document: Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and...