| The protein-phosphatase inhibitor okadaic acid mimics MSH-induced and melatonin-reversible melanosome dispersion in Xenopus laevis melanophores. | |
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MedLine Citation:
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PMID: 1329076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study describes the ability of 315 nM okadaic acid to induce melanosome dispersion in cultured Xenopus laevis melanophores. This effect of okadaic acid is similar to that of a-melanocyte stimulating hormone (MSH) and can be reversed by melatonin treatment; it indicates that a member of the protein-phosphatase 1 or 2A families must be active for maintenance of the aggregated state. Higher concentrations of okadaic acid (1 microM) attenuate the response of Xenopus melanophores to melatonin leading to the hypothesis that melatonin action is mediated by the calcium/calmodulin activated phosphatase 2B. This hypothesis seems unlikely, however, since the calcium/calmodulin inhibitors TFP and W7 do not prevent melatonin-induced pigment aggregation, but instead induce aggregation on their own. |
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Authors:
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B Cozzi; M D Rollag |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society Volume: 5 ISSN: 0893-5785 ISO Abbreviation: Pigment Cell Res. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-12 Completed Date: 1992-11-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8800247 Medline TA: Pigment Cell Res Country: DENMARK |
Other Details:
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Languages: eng Pagination: 148-54 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Calmodulin / metabolism Cells, Cultured / drug effects Ethers, Cyclic / pharmacology* Melanocyte-Stimulating Hormones / antagonists & inhibitors, pharmacology Melanocytes / drug effects* Melanophores / drug effects* Melatonin / pharmacology Okadaic Acid Phosphoprotein Phosphatases / antagonists & inhibitors* Sulfonamides Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Ethers, Cyclic; 0/Sulfonamides; 65595-90-6/W 7; 73-31-4/Melatonin; 7440-70-2/Calcium; 78111-17-8/Okadaic Acid; 9002-79-3/Melanocyte-Stimulating Hormones; EC 3.1.3.16/Phosphoprotein Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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