Document Detail

The protein-phosphatase inhibitor okadaic acid mimics MSH-induced and melatonin-reversible melanosome dispersion in Xenopus laevis melanophores.
MedLine Citation:
PMID:  1329076     Owner:  NLM     Status:  MEDLINE    
The present study describes the ability of 315 nM okadaic acid to induce melanosome dispersion in cultured Xenopus laevis melanophores. This effect of okadaic acid is similar to that of a-melanocyte stimulating hormone (MSH) and can be reversed by melatonin treatment; it indicates that a member of the protein-phosphatase 1 or 2A families must be active for maintenance of the aggregated state. Higher concentrations of okadaic acid (1 microM) attenuate the response of Xenopus melanophores to melatonin leading to the hypothesis that melatonin action is mediated by the calcium/calmodulin activated phosphatase 2B. This hypothesis seems unlikely, however, since the calcium/calmodulin inhibitors TFP and W7 do not prevent melatonin-induced pigment aggregation, but instead induce aggregation on their own.
B Cozzi; M D Rollag
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  5     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-12     Completed Date:  1992-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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MeSH Terms
Calcium / metabolism
Calmodulin / metabolism
Cells, Cultured / drug effects
Ethers, Cyclic / pharmacology*
Melanocyte-Stimulating Hormones / antagonists & inhibitors,  pharmacology
Melanocytes / drug effects*
Melanophores / drug effects*
Melatonin / pharmacology
Okadaic Acid
Phosphoprotein Phosphatases / antagonists & inhibitors*
Xenopus laevis
Reg. No./Substance:
0/Calmodulin; 0/Ethers, Cyclic; 0/Sulfonamides; 65595-90-6/W 7; 73-31-4/Melatonin; 7440-70-2/Calcium; 78111-17-8/Okadaic Acid; 9002-79-3/Melanocyte-Stimulating Hormones; EC Phosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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