Document Detail


The protein and lipid composition of arterial elastin and its relationship to lipid accumulation in the atherosclerotic plaque.
MedLine Citation:
PMID:  5097573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elastin preparations from intimal layers and the media of normal and atherosclerotic human aortae were analyzed for protein and lipid content. In atherosclerotic aortae, elastin from plaques was compared with elastin from adjacent normal appearing areas of the same aorta. Arterial elastin purified by alkaline extraction appeared to be a protein-lipid complex containing free and ester cholesterol, phospholipids, and triglycerides. The lipid component of normal arterial elastin was small (1-2%). With increasing severity of atherosclerosis, there was a progressive accumulation of lipid in intimal elastin from plaques, reaching a mean lipid content of 37% in severe plaques. The increase in the lipid content of plaque elastic preparations was mainly due to large increases in cholesterol, over 80% of which was cholesteryl ester. This deposition of cholesterol in plaque elastin accounted for 20-34% of the total cholesterol content of the plaque. The increased lipid deposition in plaque elastin was associated with alterations in the amino acid composition of plaque elastin. In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly. The amino acid and lipid composition of elastin from normal appearing aortic areas was comparable to that of normal arterial elastin except for intimal elastin directly adjacent to and medial elastin directly below the most severe plaques.The data indicate that the focal lipid deposition in early atherosclerotic plaques is due to a large extent to lipid accumulations in altered elastin protein of localized intimal areas. Continued lipid deposition in altered elastin appears to contribute substantially to the progressive lipid accumulation in the plaque. The study suggests that elastin of intimal elastic membranes may play an important role in the pathogenesis and progression of atherosclerosis.
Authors:
D M Kramsch; C Franzblau; W Hollander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  50     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1971 Aug 
Date Detail:
Created Date:  1971-12-08     Completed Date:  1971-12-08     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1666-77     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aorta / analysis
Arginine / analysis
Arteriosclerosis / etiology,  metabolism*
Aspartic Acid / analysis
Cholesterol / analysis,  metabolism
Elastin / analysis*,  biosynthesis
Esters / analysis
Female
Glutamates / analysis
Histidine / analysis
Humans
Lipids / analysis*
Lung / analysis
Lysine / analysis
Male
Middle Aged
Phospholipids / analysis
Proteins / analysis*
Serine / analysis
Threonine / analysis
Triglycerides / analysis
Tritium
Chemical
Reg. No./Substance:
0/Esters; 0/Glutamates; 0/Lipids; 0/Phospholipids; 0/Proteins; 0/Triglycerides; 10028-17-8/Tritium; 56-45-1/Serine; 56-84-8/Aspartic Acid; 56-87-1/Lysine; 57-88-5/Cholesterol; 71-00-1/Histidine; 72-19-5/Threonine; 74-79-3/Arginine; 9007-58-3/Elastin
Comments/Corrections

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