| A protein-free diet alters small intestinal architecture and digestive enzyme activities in rats. | |
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MedLine Citation:
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PMID: 16438914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The consequences of feeding a protein-free (PF) diet, as compared to casein, on gut characteristics were studied in slightly energy-restricted rats fed similar amounts of feed for 10 d. The weight and pH of fresh digesta in the stomach were lower (P = 0.045 and P = 0.016). However, the weight of fresh digesta in the other segments and gut tissue weight were not significantly affected by the diet (P > 0.05). Small intestinal crypt depth, width and area were reduced by 13, 23 and 37%, respectively (P = 0.011, P = 0.004 and P = 0.001), and villus width tended to be smaller (P = 0.057), with the PF diet. Villus height to crypt depth ratio was also lower with the PF diet in the duodenum and ileum, respectively (P < 0.05). Finally, the specific activities of alkaline phosphatase and aminopeptidase N were reduced by 36 to 38% at different sites of the small intestine in the rats fed the PF diet (P < 0.05). In conclusion, chronic consumption of a protein-free diet altered the intestinal villus-crypt architecture and enzyme activities in rats. |
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Authors:
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Carlos Alexander Montoya; Pascal Leterme; Jean-Paul Lalles |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproduction, nutrition, development Volume: 46 ISSN: 0926-5287 ISO Abbreviation: Reprod. Nutr. Dev. Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-01-27 Completed Date: 2006-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913069 Medline TA: Reprod Nutr Dev Country: France |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Universidad Nacional de Colombia, Departamento de Produccion Animal, Carrera 32 Chapinero, Palmira (Valle), Colombia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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metabolism Animals Antigens, CD13 / metabolism Caseins / administration & dosage Diet, Protein-Restricted* Dietary Proteins / administration & dosage* Female Hydrogen-Ion Concentration Intestinal Mucosa / anatomy & histology, drug effects*, enzymology, growth & development Intestine, Small* / anatomy & histology, drug effects, enzymology, growth & development Organ Size Random Allocation Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Dietary Proteins; EC 3.1.3.1/Alkaline Phosphatase; EC 3.4.11.2/Antigens, CD13 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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