| A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres. | |
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MedLine Citation:
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PMID: 15451441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study we developed alginate-chitosan-poly(lactic-co-glycolic acid) (PLGA) composite microspheres to elevate protein entrapment efficiency and decrease its burst release. Bovine serum albumin (BSA), which used as the model protein, was entrapped into the alginate microcapsules by a modified emulsification method in an isopropyl alcohol-washed way. The rapid drug releases were sustained by chitosan coating. To obtain the desired release properties, the alginate-chitosan microcapsules were further incorporated in the PLGA to form the composite microspheres. The average diameter of the composite microcapsules was 31+/-9microm and the encapsulation efficiency was 81-87%, while that of conventional PLGA microspheres was just 61-65%. Furthermore, the burst releases at 1h of BSA entrapped in composite microspheres which containing PLGA (50:50) and PLGA (70:30) decreased to 24% and 8% in PBS, and further decreased to 5% and 2% in saline. On the contrary, the burst releases of conventional PLGA microspheres were 48% and 52% in PBS, respectively. Moreover, the release profiles could be manipulated by regulating the ratios of poly(lactic acid) to poly(glycolic acid) in the composite microspheres. |
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Authors:
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Cai-Hong Zheng; Jian-Qing Gao; Ye-Ping Zhang; Wen-Quan Liang |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 323 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2004-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1321-7 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alginates
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chemistry* Body Fluids / chemistry* Chitin / analogs & derivatives*, chemistry* Chitosan Contraceptive Agents / administration & dosage, chemistry* Diffusion Glucuronic Acid / chemistry* Hexuronic Acids / chemistry* Lactic Acid / chemistry* Materials Testing Microspheres Particle Size Polyglycolic Acid / chemistry* Polymers / chemistry* Proteins / administration & dosage, chemistry Serum Albumin, Bovine / administration & dosage*, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Contraceptive Agents; 0/Hexuronic Acids; 0/Polymers; 0/Proteins; 0/Serum Albumin, Bovine; 0/polylactic acid-polyglycolic acid copolymer; 1398-61-4/Chitin; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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