| The protective role of polyphenols in cytotoxicity of hydrogen peroxide. | |
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MedLine Citation:
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PMID: 1370984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A variety of synthetic and natural polyphenols protect mammalian cells from hydrogen peroxide (H2O2). Cytotoxicity of H2O2 on Chinese hamster V79 cells was assessed with a colony formation assay, and several polyphenols prevented the decrease in the number of colonies caused by H2O2. A study of the structure-activity relationship revealed that affinity of the polyphenols for the cell membrane and the presence of an ortho-dihydroxy moiety in their structure proved essential to this protection. |
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Authors:
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T Nakayama; T Niimi; T Osawa; S Kawakishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 281 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-06 Completed Date: 1992-03-06 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 77-80 Citation Subset: IM |
Affiliation:
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Department of Food Science and Technology, Faculty of Agriculture, Nagoya University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Cell Line Cell Membrane / drug effects Colony-Forming Units Assay Cricetinae Flavonoids* Hydrogen Peroxide / antagonists & inhibitors, toxicity* Phenols / pharmacology* Polymers / pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Flavonoids; 0/Phenols; 0/Polymers; 0/polyphenols; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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