Document Detail

The protective role of polyphenols in cytotoxicity of hydrogen peroxide.
MedLine Citation:
PMID:  1370984     Owner:  NLM     Status:  MEDLINE    
A variety of synthetic and natural polyphenols protect mammalian cells from hydrogen peroxide (H2O2). Cytotoxicity of H2O2 on Chinese hamster V79 cells was assessed with a colony formation assay, and several polyphenols prevented the decrease in the number of colonies caused by H2O2. A study of the structure-activity relationship revealed that affinity of the polyphenols for the cell membrane and the presence of an ortho-dihydroxy moiety in their structure proved essential to this protection.
T Nakayama; T Niimi; T Osawa; S Kawakishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  281     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-06     Completed Date:  1992-03-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Department of Food Science and Technology, Faculty of Agriculture, Nagoya University, Japan.
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MeSH Terms
Antioxidants / pharmacology*
Cell Line
Cell Membrane / drug effects
Colony-Forming Units Assay
Hydrogen Peroxide / antagonists & inhibitors,  toxicity*
Phenols / pharmacology*
Polymers / pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Antioxidants; 0/Flavonoids; 0/Phenols; 0/Polymers; 0/polyphenols; 7722-84-1/Hydrogen Peroxide

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